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- W2029414556 abstract "Summary o 1. In a series of 11 experiments in 10 mongrel dogs, closed chest cardiopulmonary bypass was begun 1 to 35 min after all evidences of cardiorespiratory function had ceased following exsanguination. The animals had been previously heparinized and cannulated. 2. Heart function could be restored after 1 hr of perfusion in seven experiments; in three of five animals with no evidence of cardiorespiratory function for 30 min or more, effective cardiac function returned after resuscitation. Surface pH of the heart rose to above 7 units after 1 hr of perfusion, suggesting relative integrity of the myocardial diphosphopyridine-nucleotide-FPN cytochrome oxidase transport system. 3. From this small series of experiments, it would appear that clinical cadaver perfusion may be carried out 30 or more min after death with some expectation of restoring heart (but not brain) function. 4. It remains to be shown that a heart obtained under these circumstances is indeed transplantable and will maintain long term functional integrity." @default.
- W2029414556 created "2016-06-24" @default.
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- W2029414556 date "1968-09-01" @default.
- W2029414556 modified "2023-09-24" @default.
- W2029414556 title "Experimental hypothermic closed chest cardiopulmonary bypass" @default.
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- W2029414556 doi "https://doi.org/10.1016/s0011-2240(68)80152-x" @default.
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