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- W2029421229 abstract "Kneading and coevaporate procedures were used in an endeavour to prepare cyclodextrin inclusion complexes of the antimycotic drug miconazole. Crystalline miconazole was present in the preparations containing β-cyclodextrin. A kneading product of miconazole and hydroxypropyl-β-cyclodextrin, molar ratio 1:2, was amorphous. It might be a genuine inclusion complex or more probably a mixture of amorphous miconazole and amorphous hydroxypropyl-β-cyclodextrin. The antimycotic effect of the amorphous kneading product was tested against a strain of Candida albicans in a fluid medium. The product had a fungicidal effect whereas a physical mixture of miconazole and hydroxypropyl-β-cyclodextrin only inhibited the growth of the fungus. The kneading product had an effect which was similar to the effect of the water-soluble miconazole nitrate salt. It was observed during the study that commercially available miconazole from different manufacturers contained at least two different crystal forms of the drug." @default.
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- W2029421229 date "1993-07-01" @default.
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- W2029421229 title "Polymorphism of miconazole during preparation of solid systems of the drug and β-cyclodextrins" @default.
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- W2029421229 doi "https://doi.org/10.1016/0031-6865(93)90007-s" @default.
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