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• W2029424531 abstract "The present study aims to image the 18-kDa translocator protein (TSPO; formerly known as the peripheral benzodiazepine receptor) in a preclinical human breast cancer (BC) xenograft mouse model with positron-emission tomography (PET). An automated radiosynthesis of [18F]-N-(2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide ([18F]FEPPA) was validated for human use using a commercial synthesis module and resulted in a high radiochemical yield (30%±8%, uncorrected; n=54) and specific activity (6±4 Ci/μmol). Tumor uptake of [18F]FEPPA in mice bearing subcutaneous MDA-MB-231 BC xenografts was evaluated by PET-computed tomography imaging and ex vivo biodistribution studies. Although the tumor was successfully visualized, ex vivo biodistribution studies revealed low tumor uptake (0.7%ID/g), with the majority of radioactivity distributed in the spleen, muscle, and heart despite high TSPO expression in this cell line. Our laboratory routinely prepares [18F]FEPPA for human-imaging studies in the central nervous system, and we envision that radiopharmaceuticals that target the TSPO have the potential for imaging macrophages in the tumor microenvironment." @default.
• W2029424531 created "2016-06-24" @default.
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• W2029424531 date "2013-04-01" @default.
• W2029424531 modified "2023-09-28" @default.
• W2029424531 title "Positron-Emission Tomography Imaging of the TSPO with [¹⁸F]FEPPA in a Preclinical Breast Cancer Model" @default.
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• W2029424531 doi "https://doi.org/10.1089/cbr.2012.1196" @default.
• W2029424531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23350894" @default.
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