Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029431060> ?p ?o ?g. }
- W2029431060 endingPage "1062" @default.
- W2029431060 startingPage "1053" @default.
- W2029431060 abstract "Gap junctions mediate electrical and metabolic communication between cells in almost all tissues and are proposed to play important roles in cellular growth control, differentiation and embryonic development. Gap junctional communication and channel assembly were suggested to be regulated by interaction of connexins with different proteins including kinases and phosphatases. Here, we identified the tumor susceptibility gene 101 (TSG101) protein to bind to the carboxyterminal tail of connexin45 in a yeast two-hybrid protein interaction screen. Glutathione S-transferase pull down experiments and immunoprecipitation revealed that not only connexin45 but also connexin30.2, -36, and -43 carboxyterminal regions were associated with TSG101 protein in pull down analyses and that connexin31, -43 and -45 co-precipitate with endogenous TSG101 protein in lysates from HM1 embryonic stem cells. TSG101 has been shown to be involved in cell cycle control, transcriptional regulation and turnover of endocytosed proteins. Thus, we decided to study the functional role of this interaction. SiRNA mediated knock down of TSG101 in HM1 embryonic stem cells led to increased levels of connexin43 and -45, prolonged half life of these connexins and increased transfer of microinjected Lucifer yellow. Our results suggest that TSG101 is involved in the degradation of connexins via interaction with connexin proteins." @default.
- W2029431060 created "2016-06-24" @default.
- W2029431060 creator A5002846614 @default.
- W2029431060 creator A5004449695 @default.
- W2029431060 creator A5009380610 @default.
- W2029431060 creator A5011892155 @default.
- W2029431060 creator A5024202994 @default.
- W2029431060 creator A5066766879 @default.
- W2029431060 creator A5069542871 @default.
- W2029431060 creator A5075657974 @default.
- W2029431060 creator A5091223831 @default.
- W2029431060 date "2009-04-01" @default.
- W2029431060 modified "2023-09-26" @default.
- W2029431060 title "The TSG101 protein binds to connexins and is involved in connexin degradation" @default.
- W2029431060 cites W1523314824 @default.
- W2029431060 cites W1964525036 @default.
- W2029431060 cites W1965028987 @default.
- W2029431060 cites W1965808925 @default.
- W2029431060 cites W1966595105 @default.
- W2029431060 cites W1969330640 @default.
- W2029431060 cites W1972304812 @default.
- W2029431060 cites W1975169487 @default.
- W2029431060 cites W1975325221 @default.
- W2029431060 cites W1975329922 @default.
- W2029431060 cites W1978854208 @default.
- W2029431060 cites W1979573002 @default.
- W2029431060 cites W1987594610 @default.
- W2029431060 cites W1988419855 @default.
- W2029431060 cites W1996835624 @default.
- W2029431060 cites W2006423074 @default.
- W2029431060 cites W2013736577 @default.
- W2029431060 cites W2017203200 @default.
- W2029431060 cites W2019987740 @default.
- W2029431060 cites W2027088984 @default.
- W2029431060 cites W2027374042 @default.
- W2029431060 cites W2032962887 @default.
- W2029431060 cites W2033975718 @default.
- W2029431060 cites W2035830214 @default.
- W2029431060 cites W2039974624 @default.
- W2029431060 cites W2043565517 @default.
- W2029431060 cites W2045686292 @default.
- W2029431060 cites W2052376766 @default.
- W2029431060 cites W2055973506 @default.
- W2029431060 cites W2063597699 @default.
- W2029431060 cites W2064898884 @default.
- W2029431060 cites W2066604682 @default.
- W2029431060 cites W2067670754 @default.
- W2029431060 cites W2068690732 @default.
- W2029431060 cites W2069403120 @default.
- W2029431060 cites W2075977132 @default.
- W2029431060 cites W2082565834 @default.
- W2029431060 cites W2101218054 @default.
- W2029431060 cites W2101848641 @default.
- W2029431060 cites W2109713419 @default.
- W2029431060 cites W2118450542 @default.
- W2029431060 cites W2125634312 @default.
- W2029431060 cites W2128536543 @default.
- W2029431060 cites W2130448025 @default.
- W2029431060 cites W2132326343 @default.
- W2029431060 cites W2138885980 @default.
- W2029431060 cites W2145625720 @default.
- W2029431060 cites W2161305913 @default.
- W2029431060 cites W2165434330 @default.
- W2029431060 cites W2171415935 @default.
- W2029431060 cites W2172240440 @default.
- W2029431060 doi "https://doi.org/10.1016/j.yexcr.2008.12.025" @default.
- W2029431060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19210987" @default.
- W2029431060 hasPublicationYear "2009" @default.
- W2029431060 type Work @default.
- W2029431060 sameAs 2029431060 @default.
- W2029431060 citedByCount "36" @default.
- W2029431060 countsByYear W20294310602012 @default.
- W2029431060 countsByYear W20294310602013 @default.
- W2029431060 countsByYear W20294310602014 @default.
- W2029431060 countsByYear W20294310602015 @default.
- W2029431060 countsByYear W20294310602016 @default.
- W2029431060 countsByYear W20294310602017 @default.
- W2029431060 countsByYear W20294310602018 @default.
- W2029431060 countsByYear W20294310602019 @default.
- W2029431060 countsByYear W20294310602020 @default.
- W2029431060 countsByYear W20294310602021 @default.
- W2029431060 countsByYear W20294310602022 @default.
- W2029431060 countsByYear W20294310602023 @default.
- W2029431060 crossrefType "journal-article" @default.
- W2029431060 hasAuthorship W2029431060A5002846614 @default.
- W2029431060 hasAuthorship W2029431060A5004449695 @default.
- W2029431060 hasAuthorship W2029431060A5009380610 @default.
- W2029431060 hasAuthorship W2029431060A5011892155 @default.
- W2029431060 hasAuthorship W2029431060A5024202994 @default.
- W2029431060 hasAuthorship W2029431060A5066766879 @default.
- W2029431060 hasAuthorship W2029431060A5069542871 @default.
- W2029431060 hasAuthorship W2029431060A5075657974 @default.
- W2029431060 hasAuthorship W2029431060A5091223831 @default.
- W2029431060 hasConcept C102747710 @default.
- W2029431060 hasConcept C104317684 @default.
- W2029431060 hasConcept C143876685 @default.
- W2029431060 hasConcept C145059251 @default.
- W2029431060 hasConcept C145103041 @default.