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- W2029438034 abstract "Fluorescence diffuse optical tomography (FDOT) can provide important information in biomedical studies. In this ill-posed problem, suppression of background tissue autofluorescence is of utmost importance. We report a method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds. Even with the intrinsic autofluorescence from the phantom only, the reconstruction of the nanoparticles is of much better quality than the reconstruction of a Stokes-shifting dye. In addition, the nonlinear power dependence leads to more confined reconstructions and may increase the resolution in FDOT." @default.
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- W2029438034 date "2009-06-22" @default.
- W2029438034 modified "2023-09-26" @default.
- W2029438034 title "Fluorescence diffuse optical tomography using upconverting nanoparticles" @default.
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- W2029438034 doi "https://doi.org/10.1063/1.3156857" @default.
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