FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029442922> ?p ?o ?g. }

• W2029442922 endingPage "1340" @default.
• W2029442922 startingPage "1334" @default.
• W2029442922 abstract "Gallic acid (GA) is widely distributed in various plants and foods, and its various biological effects have been reported. Here, we evaluated the effects of GA on HeLa cells in relation to cell growth inhibition and death. HeLa cell growth was diminished with an IC(50) of approximately 80 microM GA at 24h whereas an IC(50) of GA in human umbilical vein endothelial cells (HUVEC) was approximately 400 microM. GA-induced apoptosis and/or necrosis in HeLa cells and HUVEC, which was accompanied by the loss of mitochondrial membrane potential (MMP; DeltaPsi(m)). The percentages of MMP (DeltaPsi(m)) loss cells and death cells were lower in HUVEC than HeLa cells. All the tested caspase inhibitors (pan-caspase, caspase-3, -8 or -9 inhibitor) significantly rescued HeLa cells from GA-induced cell death. GA increased reactive oxygen species (ROS) level and GSH (glutathione) depleted cell number in HeLa cells. Caspase inhibitors reduced GSH depleted cell number but not ROS level in GA-treated HeLa cells. In conclusion, GA inhibited the growth of HeLa cells and HUVEC via apoptosis and/or necrosis. The susceptibility of HeLa cells to GA was higher than that of HUVEC. GA-induced HeLa cell death was accompanied by ROS increase and GSH depletion." @default.
• W2029442922 created "2016-06-24" @default.
• W2029442922 creator A5017130721 @default.
• W2029442922 creator A5054329420 @default.
• W2029442922 creator A5068413798 @default.
• W2029442922 creator A5079501124 @default.
• W2029442922 date "2010-05-01" @default.
• W2029442922 modified "2023-10-02" @default.
• W2029442922 title "Gallic acid inhibits the growth of HeLa cervical cancer cells via apoptosis and/or necrosis" @default.
• W2029442922 cites W1970109190 @default.
• W2029442922 cites W1974185176 @default.
• W2029442922 cites W1975097914 @default.
• W2029442922 cites W1975717755 @default.
• W2029442922 cites W1976666971 @default.
• W2029442922 cites W1976875624 @default.
• W2029442922 cites W1979995768 @default.
• W2029442922 cites W1980618862 @default.
• W2029442922 cites W1997805239 @default.
• W2029442922 cites W2002801265 @default.
• W2029442922 cites W2008510581 @default.
• W2029442922 cites W2009864041 @default.
• W2029442922 cites W2010298858 @default.
• W2029442922 cites W2013920162 @default.
• W2029442922 cites W2019334036 @default.
• W2029442922 cites W2021565484 @default.
• W2029442922 cites W2025128734 @default.
• W2029442922 cites W202963727 @default.
• W2029442922 cites W2031855999 @default.
• W2029442922 cites W2035476026 @default.
• W2029442922 cites W2047665422 @default.
• W2029442922 cites W2053451770 @default.
• W2029442922 cites W2062145582 @default.
• W2029442922 cites W2067036546 @default.
• W2029442922 cites W2071164359 @default.
• W2029442922 cites W2076840000 @default.
• W2029442922 cites W2098134137 @default.
• W2029442922 cites W2102802372 @default.
• W2029442922 cites W2111649506 @default.
• W2029442922 cites W2115734998 @default.
• W2029442922 cites W2119331100 @default.
• W2029442922 cites W2121793916 @default.
• W2029442922 cites W2151501496 @default.
• W2029442922 cites W2165415169 @default.
• W2029442922 cites W2168041765 @default.
• W2029442922 cites W2168389275 @default.
• W2029442922 doi "https://doi.org/10.1016/j.fct.2010.02.034" @default.
• W2029442922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20197077" @default.
• W2029442922 hasPublicationYear "2010" @default.
• W2029442922 type Work @default.
• W2029442922 sameAs 2029442922 @default.
• W2029442922 citedByCount "150" @default.
• W2029442922 countsByYear W20294429222012 @default.
• W2029442922 countsByYear W20294429222013 @default.
• W2029442922 countsByYear W20294429222014 @default.
• W2029442922 countsByYear W20294429222015 @default.
• W2029442922 countsByYear W20294429222016 @default.
• W2029442922 countsByYear W20294429222017 @default.
• W2029442922 countsByYear W20294429222018 @default.
• W2029442922 countsByYear W20294429222019 @default.
• W2029442922 countsByYear W20294429222020 @default.
• W2029442922 countsByYear W20294429222021 @default.
• W2029442922 countsByYear W20294429222022 @default.
• W2029442922 countsByYear W20294429222023 @default.
• W2029442922 crossrefType "journal-article" @default.
• W2029442922 hasAuthorship W2029442922A5017130721 @default.
• W2029442922 hasAuthorship W2029442922A5054329420 @default.
• W2029442922 hasAuthorship W2029442922A5068413798 @default.
• W2029442922 hasAuthorship W2029442922A5079501124 @default.
• W2029442922 hasConcept C121608353 @default.
• W2029442922 hasConcept C1491633281 @default.
• W2029442922 hasConcept C153911025 @default.
• W2029442922 hasConcept C181199279 @default.
• W2029442922 hasConcept C185592680 @default.
• W2029442922 hasConcept C190283241 @default.
• W2029442922 hasConcept C2777366897 @default.
• W2029442922 hasConcept C2778004101 @default.
• W2029442922 hasConcept C2778362808 @default.
• W2029442922 hasConcept C31573885 @default.
• W2029442922 hasConcept C48349386 @default.
• W2029442922 hasConcept C503630168 @default.
• W2029442922 hasConcept C538909803 @default.
• W2029442922 hasConcept C54355233 @default.
• W2029442922 hasConcept C55493867 @default.
• W2029442922 hasConcept C62112901 @default.
• W2029442922 hasConcept C81885089 @default.
• W2029442922 hasConcept C86803240 @default.
• W2029442922 hasConcept C95444343 @default.
• W2029442922 hasConcept C96232424 @default.
• W2029442922 hasConceptScore W2029442922C121608353 @default.
• W2029442922 hasConceptScore W2029442922C1491633281 @default.
• W2029442922 hasConceptScore W2029442922C153911025 @default.
• W2029442922 hasConceptScore W2029442922C181199279 @default.
• W2029442922 hasConceptScore W2029442922C185592680 @default.
• W2029442922 hasConceptScore W2029442922C190283241 @default.
• W2029442922 hasConceptScore W2029442922C2777366897 @default.
• W2029442922 hasConceptScore W2029442922C2778004101 @default.
• W2029442922 hasConceptScore W2029442922C2778362808 @default.
• W2029442922 hasConceptScore W2029442922C31573885 @default.

• next