Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029444364> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2029444364 endingPage "184" @default.
- W2029444364 startingPage "179" @default.
- W2029444364 abstract "Organ-specific extracellular matrix (ECM) determines metastasis formation by regulating tumor cell proliferation. Hepatocyte-derived ECM enhances proliferation of colon cancer cell lines by increasing expression of tyrosine kinase receptors of the erb-B family. The active components in the ECM are the heparan sulfates, which are highly heterogeneous in their chemistry and size. We determined the effect of heparan sulfate disaccharides, of defined chemistry and present in high amounts in the liver heparan sulfate chains, on the proliferation of colon cancer cell lines and investigated the mechanism involved. The low-metastatic cell line KM12 was stimulated to proliferate by a highly sulfated disaccharide, found in the highest amounts in hepatocyte-derived heparan sulfate. Growth of the highly metastatic cell line KM12SM was inhibited by the second most common disaccharide in hepatocyte-derived heparan sulfate. The effect of both disaccharides was not accompanied by changes in the expression of erb-B1, erb-B2, erb-B3 or heregulin-alpha. We determined whether the disaccharides modified the signal-transduction pathways mediated by the erb-B receptors. The erb-B2-specific tyrosine kinase inhibitor AG825 abolished the enhancement of KM12 cell proliferation by the stimulatory disaccharide. This disaccharide increased tyrosine phosphorylation of erb-B1 and erb-B2 receptors, effects that were abolished by AG825. Moreover, the disaccharide caused increased expression of cyclin D1 and of activated MAP kinase, again reduced in the presence of the inhibitor AG825. The growth-inhibitory disaccharide reduced phosphorylation of erb-B1, but not of erb-B2, receptors in KM12SM cells. In conclusion, not only hepatocyte-derived heparan sulfate but also disaccharide molecules derived from heparan sulfate can affect colon cancer cell proliferation. Their effect is mediated by modulation of the erb-B signal transduction." @default.
- W2029444364 created "2016-06-24" @default.
- W2029444364 creator A5013357405 @default.
- W2029444364 creator A5036050247 @default.
- W2029444364 creator A5065040805 @default.
- W2029444364 creator A5066248911 @default.
- W2029444364 creator A5077072265 @default.
- W2029444364 date "2002-04-22" @default.
- W2029444364 modified "2023-10-14" @default.
- W2029444364 title "Heparin-derived disaccharides modulate proliferation andErb-B2-mediated signal transduction in colon cancer cell lines" @default.
- W2029444364 cites W1487884828 @default.
- W2029444364 cites W1488703026 @default.
- W2029444364 cites W1559464451 @default.
- W2029444364 cites W1608390571 @default.
- W2029444364 cites W1675828477 @default.
- W2029444364 cites W1965081294 @default.
- W2029444364 cites W1967647822 @default.
- W2029444364 cites W1974873948 @default.
- W2029444364 cites W1979045210 @default.
- W2029444364 cites W2002796256 @default.
- W2029444364 cites W2005092901 @default.
- W2029444364 cites W2005374750 @default.
- W2029444364 cites W2031521660 @default.
- W2029444364 cites W2039563652 @default.
- W2029444364 cites W2043229624 @default.
- W2029444364 cites W2050909459 @default.
- W2029444364 cites W2061511365 @default.
- W2029444364 cites W2067188105 @default.
- W2029444364 cites W2070842899 @default.
- W2029444364 cites W2078611937 @default.
- W2029444364 cites W2123206362 @default.
- W2029444364 cites W2141693234 @default.
- W2029444364 cites W2147592015 @default.
- W2029444364 cites W4211075026 @default.
- W2029444364 doi "https://doi.org/10.1002/ijc.10363" @default.
- W2029444364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11979431" @default.
- W2029444364 hasPublicationYear "2002" @default.
- W2029444364 type Work @default.
- W2029444364 sameAs 2029444364 @default.
- W2029444364 citedByCount "13" @default.
- W2029444364 countsByYear W20294443642012 @default.
- W2029444364 countsByYear W20294443642016 @default.
- W2029444364 crossrefType "journal-article" @default.
- W2029444364 hasAuthorship W2029444364A5013357405 @default.
- W2029444364 hasAuthorship W2029444364A5036050247 @default.
- W2029444364 hasAuthorship W2029444364A5065040805 @default.
- W2029444364 hasAuthorship W2029444364A5066248911 @default.
- W2029444364 hasAuthorship W2029444364A5077072265 @default.
- W2029444364 hasBestOaLocation W20294443641 @default.
- W2029444364 hasConcept C11960822 @default.
- W2029444364 hasConcept C153074725 @default.
- W2029444364 hasConcept C185592680 @default.
- W2029444364 hasConcept C189165786 @default.
- W2029444364 hasConcept C2777346074 @default.
- W2029444364 hasConcept C2777553839 @default.
- W2029444364 hasConcept C2778041096 @default.
- W2029444364 hasConcept C55493867 @default.
- W2029444364 hasConcept C62112901 @default.
- W2029444364 hasConcept C62478195 @default.
- W2029444364 hasConcept C86803240 @default.
- W2029444364 hasConcept C95444343 @default.
- W2029444364 hasConceptScore W2029444364C11960822 @default.
- W2029444364 hasConceptScore W2029444364C153074725 @default.
- W2029444364 hasConceptScore W2029444364C185592680 @default.
- W2029444364 hasConceptScore W2029444364C189165786 @default.
- W2029444364 hasConceptScore W2029444364C2777346074 @default.
- W2029444364 hasConceptScore W2029444364C2777553839 @default.
- W2029444364 hasConceptScore W2029444364C2778041096 @default.
- W2029444364 hasConceptScore W2029444364C55493867 @default.
- W2029444364 hasConceptScore W2029444364C62112901 @default.
- W2029444364 hasConceptScore W2029444364C62478195 @default.
- W2029444364 hasConceptScore W2029444364C86803240 @default.
- W2029444364 hasConceptScore W2029444364C95444343 @default.
- W2029444364 hasIssue "2" @default.
- W2029444364 hasLocation W20294443641 @default.
- W2029444364 hasLocation W20294443642 @default.
- W2029444364 hasOpenAccess W2029444364 @default.
- W2029444364 hasPrimaryLocation W20294443641 @default.
- W2029444364 hasRelatedWork W1551427977 @default.
- W2029444364 hasRelatedWork W1968048665 @default.
- W2029444364 hasRelatedWork W1970841399 @default.
- W2029444364 hasRelatedWork W2276763293 @default.
- W2029444364 hasRelatedWork W2411592383 @default.
- W2029444364 hasRelatedWork W2414975270 @default.
- W2029444364 hasRelatedWork W2535077667 @default.
- W2029444364 hasRelatedWork W2953531832 @default.
- W2029444364 hasRelatedWork W2984149798 @default.
- W2029444364 hasRelatedWork W3152396389 @default.
- W2029444364 hasVolume "99" @default.
- W2029444364 isParatext "false" @default.
- W2029444364 isRetracted "false" @default.
- W2029444364 magId "2029444364" @default.
- W2029444364 workType "article" @default.