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- W2029451367 abstract "Tetherin/BST-2 is an important host restriction factor that limits the replication of HIV and other enveloped viruses. Tetherin is a type II membrane glycoprotein with a very unusual domain structure that allows it to engage budding virions and retain them on the plasma membrane of infected cells. Following the initial report identifying tetherin as the host cell factor targeted by the HIV-1 Vpu gene, knowledge of the molecular, structural, and cellular biology of tetherin has rapidly advanced. This paper summarizes the discovery and impact of tetherin biology on the HIV field, with a focus on recent advances in understanding its structure and function. The relevance of tetherin to replication and spread of other retroviruses is also reviewed. Tetherin is a unique host restriction factor that is likely to continue to provide new insights into host-virus interactions and illustrates well the varied ways by which host organisms defend against viral pathogens." @default.
- W2029451367 created "2016-06-24" @default.
- W2029451367 creator A5019016560 @default.
- W2029451367 creator A5022441333 @default.
- W2029451367 creator A5032363539 @default.
- W2029451367 date "2012-07-02" @default.
- W2029451367 modified "2023-09-26" @default.
- W2029451367 title "Restriction of Retroviral Replication by Tetherin/BST-2" @default.
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- W2029451367 doi "https://doi.org/10.1155/2012/424768" @default.
- W2029451367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3395152" @default.