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- W2029453350 abstract "Abstract A new procedure for the determination of novel discovery drug substance purity was developed using LC-MS coupled with charged aerosol detection (CAD) in a walk up open access system and chromatographic purity service. Chemists require an accurate high throughput methodology to monitor reactions and to provide good assurance of final compound quality. There is a need for detection methodologies, which are accurate and precise and offer rapid, inexpensive evaluation of research compound purity without the need for specific validated drug reference standards. This new approach resulted in a more accurate assessment of purity in comparison to the standard UV approach. This technique has been successful as an approach for a walk up service for chemists and also as a chromatographic purity service at low pH. Keywords: Charged aerosol detectorDetectionHigh performance liquid chromatographyMass spectrometryPurity ACKNOWLEDGMENT We thank Eddie Goodhall, (ESA Analytical, Aylsbury, Buckinghamshire, UK) for the loan of the CAD for this evaluation and also providing advice on the system." @default.
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- W2029453350 date "2008-10-22" @default.
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- W2029453350 title "Implementation of Charged Aerosol Detection in Routine Reversed Phase Liquid Chromatography Methods" @default.
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