Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029453374> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2029453374 endingPage "939" @default.
- W2029453374 startingPage "935" @default.
- W2029453374 abstract "1. The relaxant effect of KRN2391, N-cyano-N′-(2-nitroxyethyl)-3-pyridine-carboximidamide-monomethanesulfonate (with both K+ channel opener and nitrate actions), nifedipine (Ca2+ channel blocker), nitroglycerin (nitrate) and cromakalim (K+ channel opener) were investigated in isolated porcine large coronary arteries contracted by endothelin-1. These drugs inhibited endothelin-1-induced contraction in a concentration-dependent manner. 2. The relaxation induced by KRN2391 was nearly complete at their maximum effects, but nifedipine and cromakalim could not produce complete relaxation. 3. The concentration-relaxation curves for KRN2391 underwent a rightward shift in the presence of methylene blue or glibenclamide. The concentration ratios of KRN2391 calculated based on EC50 values were 2.8 and 3.7 in the presence of methylene blue and glibenclamide, respectively. 4. The concentration-relaxation curves for nitroglycerin and cromakalin underwent a rightward shift in the presence of methylene blue and glibenclamide, respectively, and the concentration ratios of nitroglycerin and cromakalim were 12.0 and 6.3. 5. These relaxant effects of KRN2391 and nitroglycerin on endothelin-1-induced contraction of porcine coronary artery were greater than those of cromakalim and nifedipine. This potent relaxant action of KRN2391 on endothelin-induced contraction is thought to be based on both a nitrate action and a K+ channel opening action." @default.
- W2029453374 created "2016-06-24" @default.
- W2029453374 creator A5016716688 @default.
- W2029453374 creator A5019842793 @default.
- W2029453374 creator A5021542575 @default.
- W2029453374 creator A5026985302 @default.
- W2029453374 creator A5047524684 @default.
- W2029453374 creator A5053324448 @default.
- W2029453374 date "1994-09-01" @default.
- W2029453374 modified "2023-09-23" @default.
- W2029453374 title "Pharmacological analysis of the inhibitory effects of KRN2391 on endothelin-1-induced contraction in isolated large coronary artery of the pig" @default.
- W2029453374 cites W1900029203 @default.
- W2029453374 cites W1974102498 @default.
- W2029453374 cites W1980182796 @default.
- W2029453374 cites W1981678742 @default.
- W2029453374 cites W1984376448 @default.
- W2029453374 cites W1991143553 @default.
- W2029453374 cites W1991982812 @default.
- W2029453374 cites W1997940160 @default.
- W2029453374 cites W2001743375 @default.
- W2029453374 cites W2011598099 @default.
- W2029453374 cites W2016537650 @default.
- W2029453374 cites W2021332865 @default.
- W2029453374 cites W2069842832 @default.
- W2029453374 cites W2074912997 @default.
- W2029453374 cites W2084935848 @default.
- W2029453374 cites W2091277681 @default.
- W2029453374 cites W2126449762 @default.
- W2029453374 cites W2155615934 @default.
- W2029453374 cites W2162804111 @default.
- W2029453374 cites W2411320449 @default.
- W2029453374 cites W29129757 @default.
- W2029453374 doi "https://doi.org/10.1016/0306-3623(94)90099-x" @default.
- W2029453374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7835640" @default.
- W2029453374 hasPublicationYear "1994" @default.
- W2029453374 type Work @default.
- W2029453374 sameAs 2029453374 @default.
- W2029453374 citedByCount "4" @default.
- W2029453374 crossrefType "journal-article" @default.
- W2029453374 hasAuthorship W2029453374A5016716688 @default.
- W2029453374 hasAuthorship W2029453374A5019842793 @default.
- W2029453374 hasAuthorship W2029453374A5021542575 @default.
- W2029453374 hasAuthorship W2029453374A5026985302 @default.
- W2029453374 hasAuthorship W2029453374A5047524684 @default.
- W2029453374 hasAuthorship W2029453374A5053324448 @default.
- W2029453374 hasConcept C126322002 @default.
- W2029453374 hasConcept C134018914 @default.
- W2029453374 hasConcept C161790260 @default.
- W2029453374 hasConcept C163415756 @default.
- W2029453374 hasConcept C185592680 @default.
- W2029453374 hasConcept C2779066535 @default.
- W2029453374 hasConcept C2779191827 @default.
- W2029453374 hasConcept C2779768347 @default.
- W2029453374 hasConcept C2780561956 @default.
- W2029453374 hasConcept C42219234 @default.
- W2029453374 hasConcept C519063684 @default.
- W2029453374 hasConcept C55493867 @default.
- W2029453374 hasConcept C555293320 @default.
- W2029453374 hasConcept C65165184 @default.
- W2029453374 hasConcept C71924100 @default.
- W2029453374 hasConcept C98274493 @default.
- W2029453374 hasConceptScore W2029453374C126322002 @default.
- W2029453374 hasConceptScore W2029453374C134018914 @default.
- W2029453374 hasConceptScore W2029453374C161790260 @default.
- W2029453374 hasConceptScore W2029453374C163415756 @default.
- W2029453374 hasConceptScore W2029453374C185592680 @default.
- W2029453374 hasConceptScore W2029453374C2779066535 @default.
- W2029453374 hasConceptScore W2029453374C2779191827 @default.
- W2029453374 hasConceptScore W2029453374C2779768347 @default.
- W2029453374 hasConceptScore W2029453374C2780561956 @default.
- W2029453374 hasConceptScore W2029453374C42219234 @default.
- W2029453374 hasConceptScore W2029453374C519063684 @default.
- W2029453374 hasConceptScore W2029453374C55493867 @default.
- W2029453374 hasConceptScore W2029453374C555293320 @default.
- W2029453374 hasConceptScore W2029453374C65165184 @default.
- W2029453374 hasConceptScore W2029453374C71924100 @default.
- W2029453374 hasConceptScore W2029453374C98274493 @default.
- W2029453374 hasIssue "5" @default.
- W2029453374 hasLocation W20294533741 @default.
- W2029453374 hasLocation W20294533742 @default.
- W2029453374 hasOpenAccess W2029453374 @default.
- W2029453374 hasPrimaryLocation W20294533741 @default.
- W2029453374 hasRelatedWork W1975638549 @default.
- W2029453374 hasRelatedWork W1991526396 @default.
- W2029453374 hasRelatedWork W2001985157 @default.
- W2029453374 hasRelatedWork W2009088033 @default.
- W2029453374 hasRelatedWork W2023351764 @default.
- W2029453374 hasRelatedWork W2029453374 @default.
- W2029453374 hasRelatedWork W2051560932 @default.
- W2029453374 hasRelatedWork W2070530007 @default.
- W2029453374 hasRelatedWork W2080722127 @default.
- W2029453374 hasRelatedWork W4211152273 @default.
- W2029453374 hasVolume "25" @default.
- W2029453374 isParatext "false" @default.
- W2029453374 isRetracted "false" @default.
- W2029453374 magId "2029453374" @default.
- W2029453374 workType "article" @default.