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• W2029453996 abstract "Fructose has recently been observed to affect brain metabolism and cognitive function in adults. Yet, possible late-onset effects by gestational fructose exposure have not been examined. We evaluated mitochondrial function in the brain of aging (15 months) male offspring of Fischer F344 rat dams fed a high-fructose diet (50% energy from fructose) during gestation and lactation. Maternal fructose exposure caused a significantly lower body weight of the offspring throughout life after weaning, while birth weight, litter size, and body fat percentage were unaffected. Isolated brain mitochondria displayed a significantly increased state 3 respiration of 8%, with the substrate combinations malate/pyruvate, malate/pyruvate/succinate, and malate/pyruvate/succinate/rotenone, as well as a significant decrease in the P/O 2 ratio, compared with the control. Uncoupling protein 5 (UCP5) protein levels increased in the fructose group compared with the control ( P = 0.03) and both UCP5 mRNA and protein levels were inversely correlated with the P/O 2 ratio ( P = 0.008 and 0.03, respectively), suggesting that UCP5 may have a role in the observed decreased phosphorylation efficiency. In conclusion, maternal high-fructose diet during gestation and lactation has long-term effects (fetal programming) on brain mitochondrial function in aging rats, which appears to be linked to an increase in UCP5 protein levels." @default.
• W2029453996 created "2016-06-24" @default.
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• W2029453996 date "2014-04-23" @default.
• W2029453996 modified "2023-10-16" @default.
• W2029453996 title "Developmental Programming by High Fructose Decreases Phosphorylation Efficiency in Aging Offspring Brain Mitochondria, Correlating with Enhanced UCP5 Expression" @default.
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• W2029453996 doi "https://doi.org/10.1038/jcbfm.2014.72" @default.
• W2029453996 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4083386" @default.
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