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- W2029454042 abstract "Abstract Alloiococcus otitidis has been found to be associated with otitis media with effusion. In this study we investigated whether TLR2 and collectins, surfactant protein A (SP‐A) and mannose‐binding lectin (MBL), interacted with A. otitidis . Both SP‐A and MBL bound to A. otitidis in a Ca 2+ ‐dependent manner. A. otitidis induced IL‐8 secretion from U937 cells and NF‐κB activation in TLR2‐transfected HEK293 cells. However, the cells transfected with the mutant TLR2 P681H did not respond to A. otitidis . In addition, A. otitidis co‐sedimented a recombinant soluble form of the extracellular TLR2 domain, indicating direct binding of the bacterium to TLR2. SP‐A and MBL augmented the phagocytosis of A. otitidis by J774A.1 cells. The collectin‐stimulated phagocytosis of A. otitidis was significantly attenuated when fucoidan and polyinosinic acid were co‐incubated. Immunoblotting analysis revealed that MBL was present in the middle ear effusion from patients with otitis media. These results demonstrate that A. otitidis is a ligand for the collectins and TLR2, and that the collectins enhance the phagocytosis of A. otitidis by macrophages, suggesting important roles of the collectins and TLR2 in the innate immunity of the middle ear against A. otitidis infection." @default.
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- W2029454042 date "2006-05-24" @default.
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- W2029454042 title "Alloiococcus otitidis is a ligand for collectins and Toll-like receptor 2, and its phagocytosis is enhanced by collectins" @default.
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- W2029454042 doi "https://doi.org/10.1002/eji.200535542" @default.
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