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• W2029454905 startingPage "382" @default.
• W2029454905 abstract "Several factors, including abdominal obesity, insulin resistance, diabetes mellitus and low levels of high-density lipoprotein cholesterol have been implicated in the high prevalence and early onset of coronary heart disease in Asian Indians. However, there are no reports regarding the role of apolipoprotein E (apo E) gene polymorphisms in premature myocardial infarction (MI) in this population. This study aimed to study the role of apo E gene polymorphisms in premature MI patients and their relation to serum lipid levels.Apo E gene polymorphisms were analysed in 35 patients with MI aged <40 years and in 45 age- and sex-matched controls using polymerase chain reaction-restriction fragment length polymorphism. Levels of serum lipids were measured in addition to the evaluation of conventional risk factors.Higher frequencies of the apo E4 allele (P<0.0001) and of genotypes E3/E4 (P<0.005) and E4/E4 (P<0.005) were recorded in the premature MI group compared with the controls. Multivariate regression analysis revealed that, after adjusting for other covariates, individuals with the E4 allele were at ~46 times higher odds to develop premature MI compared with individuals without the E4 allele [adjusted odds ratio, OR (95% confidence interval, CI): 45.7 (4.9-421.3)]. Among conventional risk factors, higher risk was observed in those having dyslipidaemia [OR (95% CI): 8.7 (0.9-86.6)] and those with a high waist : hip ratio [OR (95% CI): 5.6 (1.4-21.2)].Based on the robust association, the apo E4 allele should be considered as an independent risk factor for premature MI in Asian Indians." @default.
• W2029454905 created "2016-06-24" @default.
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• W2029454905 date "2003-07-01" @default.
• W2029454905 modified "2023-10-14" @default.
• W2029454905 title "Apolipoprotein E gene polymorphisms in patients with premature myocardial infarction: a case-controlled study in Asian Indians in North India" @default.
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• W2029454905 doi "https://doi.org/10.1258/000456303766477020" @default.
• W2029454905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12880539" @default.
• W2029454905 hasPublicationYear "2003" @default.
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