FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029454927> ?p ?o ?g. }

• W2029454927 abstract "Human haemoglobin (Hb), methaemalbumin (MHA) or rat liver microsomal cytochrome P-450 (P-450) were incubated anaerobically at microM concentrations with 1 mM carbon tetrachloride (CCl4), trichlorobromomethane (CCl3Br), chloroform (CHCl3) or methylene chloride (CH2Cl2) in presence of 1 mM sodium dithionite as the reducing agent. At the end of a 5-min incubation, haem was measured by various methods, i.e. binding spectrum with CO, pyridine-haemochromogen haem assay and porphyrin fluorescence, and compared for the four analogues. Statistically significant losses were observed, with all three haemo-protein systems, for CCi3Br, CCl4 and CHCl3, but not CH2Cl2. For Hb, the loss was greater with CCl3Br (haem assay, 63%; porphyrin fluorescence, 48%; CO binding, 24%) than with CCl4 (haem assay, 31%) or CHCl3 (haem assay, 13%). On the other hand, with MHA, CCl4 gave a dramatic loss (haem assay, 88%; porphyrin fluorescence, 83%; CO binding, 67%), which was greater than that observed with CCl3Br (haem assay, 49%; porphyrin fluorescence, 38%; CO binding, 25%). No loss was found with CHCl3. Finally, with microsomes, the inactivation was larger with CCl4 (CO binding, 58%; haem assay, 50%; porphyrin fluorescence, 33%) than with CCl3Br (CO binding, 33%; haem assay, 10%) or CHCl3 (haem assay, 9%; CO binding, 6%). In a separate set of similar experiments, an ion-pairing reverse phase HPLC method showed the formation of substrate-dependent hae-derived products during incubation of CCl3Br with Hb or microsomes, and of CCl4 with Hb. A correlation between potential for free radical formation (CCl3Br > CCl4 > CHCl3 > CH2Cl2) and extent of haem inactivation was observed with all methods for Hb, but not for microsomal P-450 or MHA. The results indicate that these halomethanes may be activated differently by different haemoproteins and suggest that their potential ability to undergo reductive metabolism may not be the only critical factor involved in P-450 haem inactivation by these chemicals." @default.
• W2029454927 created "2016-06-24" @default.
• W2029454927 creator A5004356655 @default.
• W2029454927 creator A5010787989 @default.
• W2029454927 creator A5016582909 @default.
• W2029454927 creator A5033936347 @default.
• W2029454927 creator A5039301549 @default.
• W2029454927 date "1995-06-01" @default.
• W2029454927 modified "2023-09-23" @default.
• W2029454927 title "Suicidal inactivation of haemoproteins by reductive metabolites of halomethanes: a structure-activity relationship study" @default.
• W2029454927 cites W1775749144 @default.
• W2029454927 cites W1951469402 @default.
• W2029454927 cites W1965030733 @default.
• W2029454927 cites W1979976419 @default.
• W2029454927 cites W1986580840 @default.
• W2029454927 cites W1993460900 @default.
• W2029454927 cites W1999698918 @default.
• W2029454927 cites W2000762847 @default.
• W2029454927 cites W2003717340 @default.
• W2029454927 cites W2004633535 @default.
• W2029454927 cites W2009086587 @default.
• W2029454927 cites W2012652819 @default.
• W2029454927 cites W2018639193 @default.
• W2029454927 cites W2034911590 @default.
• W2029454927 cites W2044805922 @default.
• W2029454927 cites W2045659291 @default.
• W2029454927 cites W2047956703 @default.
• W2029454927 cites W2049003916 @default.
• W2029454927 cites W2054133295 @default.
• W2029454927 cites W2068174565 @default.
• W2029454927 cites W2068869428 @default.
• W2029454927 cites W2072074016 @default.
• W2029454927 cites W2072442518 @default.
• W2029454927 cites W2084915650 @default.
• W2029454927 cites W2092709974 @default.
• W2029454927 cites W2092763649 @default.
• W2029454927 cites W2121405189 @default.
• W2029454927 cites W2135495947 @default.
• W2029454927 cites W2165583978 @default.
• W2029454927 cites W2512868977 @default.
• W2029454927 cites W29519242 @default.
• W2029454927 doi "https://doi.org/10.1016/0300-483x(95)03083-r" @default.
• W2029454927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7624875" @default.
• W2029454927 hasPublicationYear "1995" @default.
• W2029454927 type Work @default.
• W2029454927 sameAs 2029454927 @default.
• W2029454927 citedByCount "5" @default.
• W2029454927 crossrefType "journal-article" @default.
• W2029454927 hasAuthorship W2029454927A5004356655 @default.
• W2029454927 hasAuthorship W2029454927A5010787989 @default.
• W2029454927 hasAuthorship W2029454927A5016582909 @default.
• W2029454927 hasAuthorship W2029454927A5033936347 @default.
• W2029454927 hasAuthorship W2029454927A5039301549 @default.
• W2029454927 hasConcept C121332964 @default.
• W2029454927 hasConcept C178790620 @default.
• W2029454927 hasConcept C181199279 @default.
• W2029454927 hasConcept C185592680 @default.
• W2029454927 hasConcept C20705724 @default.
• W2029454927 hasConcept C2776217839 @default.
• W2029454927 hasConcept C2777315085 @default.
• W2029454927 hasConcept C2777359374 @default.
• W2029454927 hasConcept C2779480358 @default.
• W2029454927 hasConcept C2779500173 @default.
• W2029454927 hasConcept C2780768313 @default.
• W2029454927 hasConcept C2781144210 @default.
• W2029454927 hasConcept C43617362 @default.
• W2029454927 hasConcept C55493867 @default.
• W2029454927 hasConcept C62520636 @default.
• W2029454927 hasConcept C71240020 @default.
• W2029454927 hasConcept C87644729 @default.
• W2029454927 hasConcept C91881484 @default.
• W2029454927 hasConceptScore W2029454927C121332964 @default.
• W2029454927 hasConceptScore W2029454927C178790620 @default.
• W2029454927 hasConceptScore W2029454927C181199279 @default.
• W2029454927 hasConceptScore W2029454927C185592680 @default.
• W2029454927 hasConceptScore W2029454927C20705724 @default.
• W2029454927 hasConceptScore W2029454927C2776217839 @default.
• W2029454927 hasConceptScore W2029454927C2777315085 @default.
• W2029454927 hasConceptScore W2029454927C2777359374 @default.
• W2029454927 hasConceptScore W2029454927C2779480358 @default.
• W2029454927 hasConceptScore W2029454927C2779500173 @default.
• W2029454927 hasConceptScore W2029454927C2780768313 @default.
• W2029454927 hasConceptScore W2029454927C2781144210 @default.
• W2029454927 hasConceptScore W2029454927C43617362 @default.
• W2029454927 hasConceptScore W2029454927C55493867 @default.
• W2029454927 hasConceptScore W2029454927C62520636 @default.
• W2029454927 hasConceptScore W2029454927C71240020 @default.
• W2029454927 hasConceptScore W2029454927C87644729 @default.
• W2029454927 hasConceptScore W2029454927C91881484 @default.
• W2029454927 hasLocation W20294549271 @default.
• W2029454927 hasLocation W20294549272 @default.
• W2029454927 hasOpenAccess W2029454927 @default.
• W2029454927 hasPrimaryLocation W20294549271 @default.
• W2029454927 hasRelatedWork W1517537650 @default.
• W2029454927 hasRelatedWork W1569108294 @default.
• W2029454927 hasRelatedWork W1579588061 @default.
• W2029454927 hasRelatedWork W2000762847 @default.
• W2029454927 hasRelatedWork W2029454927 @default.
• W2029454927 hasRelatedWork W206188114 @default.
• W2029454927 hasRelatedWork W2068174565 @default.

• next