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• W2029456306 abstract "The NLRP3 inflammasome plays a major role in innate immune responses by activating caspase-1, resulting in secretion of interleukin-18 (IL-18) and IL-1β. Although cytosolic double-stranded RNA (dsRNA) and bacterial RNA are known to activate the NLRP3 inflammasome, the upstream sensor is unknown. We investigated the potential function of DExD/H-box RNA helicase family members (previously shown to sense cytosolic DNA and RNA to induce type 1 interferon responses) in RNA-induced NLRP3 inflammasome activation. Among the helicase family members tested, we found that targeting of DHX33 expression by short hairpin RNA efficiently blocked the activation of caspase-1 and secretion of IL-18 and IL-1β in human macrophages that were activated by cytosolic poly I:C, reoviral RNA, or bacterial RNA. DHX33 bound dsRNA via the helicase C domain. DHX33 interacted with NLRP3 and formed the inflammasome complex following stimulation with RNA. We therefore identified DHX33 as a cytosolic RNA sensor that activates the NLRP3 inflammasome." @default.
• W2029456306 created "2016-06-24" @default.
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• W2029456306 date "2013-07-01" @default.
• W2029456306 modified "2023-10-15" @default.
• W2029456306 title "The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome" @default.
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• W2029456306 doi "https://doi.org/10.1016/j.immuni.2013.07.001" @default.
• W2029456306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3756931" @default.
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