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• W2029457239 endingPage "31" @default.
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• W2029457239 abstract "Contemporary neuroscientists are paying increasing attention to subcellular, molecular and electrophysiological mechanisms underlying learning and memory processes. Recent efforts have addressed the development of transgenic mice affected at different stages of the learning process, or emulating pathological conditions involving cognition and motor-learning capabilities. However, a parallel effort is needed to develop stimulating and recording techniques suitable for use in behaving mice, in order to grasp activity-dependent neural changes taking place during the very moment of the process. These in vivo models should integrate the fragmentary information collected by different molecular and in vitro approaches. In this regard, long-term potentiation (LTP) has been proposed as the neural mechanism underlying synaptic plasticity. Moreover, N-methyl-d-aspartate (NMDA) receptors are accepted as the molecular substrate of LTP. It now seems necessary to study the relationship of both LTP and NMDA receptors with the plastic changes taking place, in selected neural structures, during actual learning. Here, we review data on the involvement of the hippocampal CA3-CA1 synapse in the acquisition of classically conditioned eyelid conditioned responses (CRs) in behaving mice. Available data show that LTP, evoked by high-frequency stimulation of Schaffer collaterals, disturbs both the acquisition of CRs and the physiological changes that occur at the CA3-CA1 synapse during learning. Moreover, the administration of NMDA-receptor antagonists is able not only to prevent LTP induction in vivo, but also to hinder the formation of both CRs and functional changes in strength of the CA3-CA1 synapse. Thus, there is experimental evidence relating activity-dependent synaptic changes taking place during actual learning with LTP mechanisms and with the role of NMDA receptors in both processes." @default.
• W2029457239 created "2016-06-24" @default.
• W2029457239 creator A5026766225 @default.
• W2029457239 creator A5088334122 @default.
• W2029457239 date "2007-05-10" @default.
• W2029457239 modified "2023-10-16" @default.
• W2029457239 title "Activity-dependent changes of the hippocampal CA3?CA1 synapse during the acquisition of associative learning in conscious mice" @default.
• W2029457239 cites W1038800568 @default.
• W2029457239 cites W1480035712 @default.
• W2029457239 cites W1543688585 @default.
• W2029457239 cites W1544320664 @default.
• W2029457239 cites W1572640432 @default.
• W2029457239 cites W1593516646 @default.
• W2029457239 cites W1611256317 @default.
• W2029457239 cites W1708267678 @default.
• W2029457239 cites W1820904250 @default.
• W2029457239 cites W1871908166 @default.
• W2029457239 cites W1893261625 @default.
• W2029457239 cites W1966783400 @default.
• W2029457239 cites W1970393142 @default.
• W2029457239 cites W1979996083 @default.
• W2029457239 cites W1983903556 @default.
• W2029457239 cites W1983923341 @default.
• W2029457239 cites W1984376917 @default.
• W2029457239 cites W1990421253 @default.
• W2029457239 cites W1990522176 @default.
• W2029457239 cites W1992320534 @default.
• W2029457239 cites W1995501474 @default.
• W2029457239 cites W1997811076 @default.
• W2029457239 cites W1997918570 @default.
• W2029457239 cites W2009782005 @default.
• W2029457239 cites W2009868507 @default.
• W2029457239 cites W2010753031 @default.
• W2029457239 cites W2011303819 @default.
• W2029457239 cites W2018187135 @default.
• W2029457239 cites W2020616048 @default.
• W2029457239 cites W2022036926 @default.
• W2029457239 cites W2022127465 @default.
• W2029457239 cites W2023626807 @default.
• W2029457239 cites W2033667632 @default.
• W2029457239 cites W2042347930 @default.
• W2029457239 cites W2043142806 @default.
• W2029457239 cites W2048782170 @default.
• W2029457239 cites W2049511526 @default.
• W2029457239 cites W2050704896 @default.
• W2029457239 cites W2055571888 @default.
• W2029457239 cites W2056459455 @default.
• W2029457239 cites W2056955495 @default.
• W2029457239 cites W2058148599 @default.
• W2029457239 cites W2058850228 @default.
• W2029457239 cites W2064711204 @default.
• W2029457239 cites W2066922852 @default.
• W2029457239 cites W2070297181 @default.
• W2029457239 cites W2072839122 @default.
• W2029457239 cites W2080285942 @default.
• W2029457239 cites W2086023016 @default.
• W2029457239 cites W2086783192 @default.
• W2029457239 cites W2087402366 @default.
• W2029457239 cites W2089502569 @default.
• W2029457239 cites W2100560922 @default.
• W2029457239 cites W2101240540 @default.
• W2029457239 cites W2101347364 @default.
• W2029457239 cites W2101620490 @default.
• W2029457239 cites W2103731399 @default.
• W2029457239 cites W2107458172 @default.
• W2029457239 cites W2107692027 @default.
• W2029457239 cites W2110724392 @default.
• W2029457239 cites W2112910777 @default.
• W2029457239 cites W2113167392 @default.
• W2029457239 cites W2113884177 @default.
• W2029457239 cites W2115065097 @default.
• W2029457239 cites W2119051448 @default.
• W2029457239 cites W2131141854 @default.
• W2029457239 cites W2133739832 @default.
• W2029457239 cites W2141998004 @default.
• W2029457239 cites W2148644678 @default.
• W2029457239 cites W2152714633 @default.
• W2029457239 cites W2170000840 @default.
• W2029457239 cites W2171826208 @default.
• W2029457239 cites W2175523146 @default.
• W2029457239 cites W2207822051 @default.
• W2029457239 cites W2235493423 @default.
• W2029457239 cites W2252383185 @default.
• W2029457239 cites W2290523363 @default.
• W2029457239 cites W2406356895 @default.
• W2029457239 cites W2784028944 @default.
• W2029457239 cites W4214891130 @default.
• W2029457239 cites W4240980427 @default.
• W2029457239 cites W4243308533 @default.
• W2029457239 cites W4255807989 @default.
• W2029457239 cites W4366658025 @default.
• W2029457239 doi "https://doi.org/10.1111/j.1601-183x.2007.00319.x" @default.
• W2029457239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17543036" @default.
• W2029457239 hasPublicationYear "2007" @default.
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