Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029458934> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2029458934 endingPage "1413" @default.
- W2029458934 startingPage "1410" @default.
- W2029458934 abstract "The potency of a series of Hexamethylene bis-acetamide (HMBA) derivatives inducing Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) was determined in LNCaP prostate cancer cells. Several compounds with unsymmetrical structures showed significantly improved activity. Distinct from HMBA, these analogs have increased hydrophobicity and can improve the short half-life of HMBA, which is one of the factors that have limited the application of HMBA in clinics. The unsymmetrical scaffolds of the new analogs provide the basis for further lead optimization of the compounds using combinatorial chemistry strategy." @default.
- W2029458934 created "2016-06-24" @default.
- W2029458934 creator A5000618507 @default.
- W2029458934 creator A5029943599 @default.
- W2029458934 creator A5037604746 @default.
- W2029458934 creator A5072377121 @default.
- W2029458934 creator A5091303181 @default.
- W2029458934 date "2014-03-01" @default.
- W2029458934 modified "2023-09-27" @default.
- W2029458934 title "Lead optimization of HMBA to develop potent HEXIM1 inducers" @default.
- W2029458934 cites W1963780232 @default.
- W2029458934 cites W2011015935 @default.
- W2029458934 cites W2032025865 @default.
- W2029458934 cites W2048295982 @default.
- W2029458934 cites W2052721854 @default.
- W2029458934 cites W2057015990 @default.
- W2029458934 cites W2092340900 @default.
- W2029458934 cites W2101370689 @default.
- W2029458934 cites W2106698189 @default.
- W2029458934 cites W2107535759 @default.
- W2029458934 cites W2116199686 @default.
- W2029458934 cites W2121971761 @default.
- W2029458934 cites W2128810491 @default.
- W2029458934 cites W2143432231 @default.
- W2029458934 cites W266859766 @default.
- W2029458934 cites W4242930200 @default.
- W2029458934 doi "https://doi.org/10.1016/j.bmcl.2014.01.025" @default.
- W2029458934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3982598" @default.
- W2029458934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24503105" @default.
- W2029458934 hasPublicationYear "2014" @default.
- W2029458934 type Work @default.
- W2029458934 sameAs 2029458934 @default.
- W2029458934 citedByCount "6" @default.
- W2029458934 countsByYear W20294589342015 @default.
- W2029458934 countsByYear W20294589342016 @default.
- W2029458934 countsByYear W20294589342017 @default.
- W2029458934 countsByYear W20294589342019 @default.
- W2029458934 crossrefType "journal-article" @default.
- W2029458934 hasAuthorship W2029458934A5000618507 @default.
- W2029458934 hasAuthorship W2029458934A5029943599 @default.
- W2029458934 hasAuthorship W2029458934A5037604746 @default.
- W2029458934 hasAuthorship W2029458934A5072377121 @default.
- W2029458934 hasAuthorship W2029458934A5091303181 @default.
- W2029458934 hasBestOaLocation W20294589342 @default.
- W2029458934 hasConcept C104317684 @default.
- W2029458934 hasConcept C121608353 @default.
- W2029458934 hasConcept C126322002 @default.
- W2029458934 hasConcept C178790620 @default.
- W2029458934 hasConcept C185592680 @default.
- W2029458934 hasConcept C202751555 @default.
- W2029458934 hasConcept C21951064 @default.
- W2029458934 hasConcept C2225953 @default.
- W2029458934 hasConcept C2776730177 @default.
- W2029458934 hasConcept C2777752112 @default.
- W2029458934 hasConcept C2779723316 @default.
- W2029458934 hasConcept C2780192828 @default.
- W2029458934 hasConcept C55493867 @default.
- W2029458934 hasConcept C57992300 @default.
- W2029458934 hasConcept C71924100 @default.
- W2029458934 hasConceptScore W2029458934C104317684 @default.
- W2029458934 hasConceptScore W2029458934C121608353 @default.
- W2029458934 hasConceptScore W2029458934C126322002 @default.
- W2029458934 hasConceptScore W2029458934C178790620 @default.
- W2029458934 hasConceptScore W2029458934C185592680 @default.
- W2029458934 hasConceptScore W2029458934C202751555 @default.
- W2029458934 hasConceptScore W2029458934C21951064 @default.
- W2029458934 hasConceptScore W2029458934C2225953 @default.
- W2029458934 hasConceptScore W2029458934C2776730177 @default.
- W2029458934 hasConceptScore W2029458934C2777752112 @default.
- W2029458934 hasConceptScore W2029458934C2779723316 @default.
- W2029458934 hasConceptScore W2029458934C2780192828 @default.
- W2029458934 hasConceptScore W2029458934C55493867 @default.
- W2029458934 hasConceptScore W2029458934C57992300 @default.
- W2029458934 hasConceptScore W2029458934C71924100 @default.
- W2029458934 hasIssue "5" @default.
- W2029458934 hasLocation W20294589341 @default.
- W2029458934 hasLocation W20294589342 @default.
- W2029458934 hasLocation W20294589343 @default.
- W2029458934 hasLocation W20294589344 @default.
- W2029458934 hasLocation W20294589345 @default.
- W2029458934 hasOpenAccess W2029458934 @default.
- W2029458934 hasPrimaryLocation W20294589341 @default.
- W2029458934 hasRelatedWork W2026241317 @default.
- W2029458934 hasRelatedWork W2027331224 @default.
- W2029458934 hasRelatedWork W2029458934 @default.
- W2029458934 hasRelatedWork W2050365843 @default.
- W2029458934 hasRelatedWork W2060214459 @default.
- W2029458934 hasRelatedWork W2213941547 @default.
- W2029458934 hasRelatedWork W2604046749 @default.
- W2029458934 hasRelatedWork W3112701574 @default.
- W2029458934 hasRelatedWork W3127713322 @default.
- W2029458934 hasRelatedWork W3183149079 @default.
- W2029458934 hasVolume "24" @default.
- W2029458934 isParatext "false" @default.
- W2029458934 isRetracted "false" @default.
- W2029458934 magId "2029458934" @default.
- W2029458934 workType "article" @default.