Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029471488> ?p ?o ?g. }
- W2029471488 abstract "Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of ligustrazine on disc degeneration, we applied a rat model. The intervertebral disc degeneration of the rats was induced by prolonged upright posture. We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1 β , cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression. In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease." @default.
- W2029471488 created "2016-06-24" @default.
- W2029471488 creator A5000005088 @default.
- W2029471488 creator A5014088164 @default.
- W2029471488 creator A5024761367 @default.
- W2029471488 creator A5026491390 @default.
- W2029471488 creator A5036627037 @default.
- W2029471488 creator A5037458498 @default.
- W2029471488 creator A5055286127 @default.
- W2029471488 creator A5056079459 @default.
- W2029471488 creator A5065999911 @default.
- W2029471488 creator A5090215277 @default.
- W2029471488 date "2014-01-01" @default.
- W2029471488 modified "2023-10-18" @default.
- W2029471488 title "Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture" @default.
- W2029471488 cites W1487142100 @default.
- W2029471488 cites W1495397680 @default.
- W2029471488 cites W1514689148 @default.
- W2029471488 cites W1521775084 @default.
- W2029471488 cites W1968264555 @default.
- W2029471488 cites W1970968094 @default.
- W2029471488 cites W1973559233 @default.
- W2029471488 cites W1984467939 @default.
- W2029471488 cites W1996030772 @default.
- W2029471488 cites W1999301612 @default.
- W2029471488 cites W2001147671 @default.
- W2029471488 cites W2009250316 @default.
- W2029471488 cites W2012137277 @default.
- W2029471488 cites W2021987372 @default.
- W2029471488 cites W2022644254 @default.
- W2029471488 cites W2030604088 @default.
- W2029471488 cites W2032955926 @default.
- W2029471488 cites W2036957524 @default.
- W2029471488 cites W2048808373 @default.
- W2029471488 cites W2050846051 @default.
- W2029471488 cites W2055472601 @default.
- W2029471488 cites W2055659480 @default.
- W2029471488 cites W2064236420 @default.
- W2029471488 cites W2070974884 @default.
- W2029471488 cites W2072086869 @default.
- W2029471488 cites W2075275458 @default.
- W2029471488 cites W2078774951 @default.
- W2029471488 cites W2079047427 @default.
- W2029471488 cites W2087702366 @default.
- W2029471488 cites W2092795144 @default.
- W2029471488 cites W2093098656 @default.
- W2029471488 cites W2094287539 @default.
- W2029471488 cites W2095465454 @default.
- W2029471488 cites W2100270372 @default.
- W2029471488 cites W2160018962 @default.
- W2029471488 cites W2017384250 @default.
- W2029471488 doi "https://doi.org/10.1155/2014/508461" @default.
- W2029471488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4020374" @default.
- W2029471488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24872832" @default.
- W2029471488 hasPublicationYear "2014" @default.
- W2029471488 type Work @default.
- W2029471488 sameAs 2029471488 @default.
- W2029471488 citedByCount "12" @default.
- W2029471488 countsByYear W20294714882015 @default.
- W2029471488 countsByYear W20294714882016 @default.
- W2029471488 countsByYear W20294714882017 @default.
- W2029471488 countsByYear W20294714882018 @default.
- W2029471488 countsByYear W20294714882019 @default.
- W2029471488 countsByYear W20294714882020 @default.
- W2029471488 crossrefType "journal-article" @default.
- W2029471488 hasAuthorship W2029471488A5000005088 @default.
- W2029471488 hasAuthorship W2029471488A5014088164 @default.
- W2029471488 hasAuthorship W2029471488A5024761367 @default.
- W2029471488 hasAuthorship W2029471488A5026491390 @default.
- W2029471488 hasAuthorship W2029471488A5036627037 @default.
- W2029471488 hasAuthorship W2029471488A5037458498 @default.
- W2029471488 hasAuthorship W2029471488A5055286127 @default.
- W2029471488 hasAuthorship W2029471488A5056079459 @default.
- W2029471488 hasAuthorship W2029471488A5065999911 @default.
- W2029471488 hasAuthorship W2029471488A5090215277 @default.
- W2029471488 hasBestOaLocation W20294714881 @default.
- W2029471488 hasConcept C104317684 @default.
- W2029471488 hasConcept C105702510 @default.
- W2029471488 hasConcept C109523444 @default.
- W2029471488 hasConcept C126322002 @default.
- W2029471488 hasConcept C127561419 @default.
- W2029471488 hasConcept C142724271 @default.
- W2029471488 hasConcept C150194340 @default.
- W2029471488 hasConcept C185592680 @default.
- W2029471488 hasConcept C204787440 @default.
- W2029471488 hasConcept C2776164576 @default.
- W2029471488 hasConcept C2776914184 @default.
- W2029471488 hasConcept C2777622882 @default.
- W2029471488 hasConcept C2777755357 @default.
- W2029471488 hasConcept C2779295440 @default.
- W2029471488 hasConcept C2779354088 @default.
- W2029471488 hasConcept C2780550940 @default.
- W2029471488 hasConcept C44575665 @default.
- W2029471488 hasConcept C519581460 @default.
- W2029471488 hasConcept C55493867 @default.
- W2029471488 hasConcept C71924100 @default.
- W2029471488 hasConceptScore W2029471488C104317684 @default.
- W2029471488 hasConceptScore W2029471488C105702510 @default.
- W2029471488 hasConceptScore W2029471488C109523444 @default.
- W2029471488 hasConceptScore W2029471488C126322002 @default.