FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029484071> ?p ?o ?g. }

• W2029484071 endingPage "154" @default.
• W2029484071 startingPage "143" @default.
• W2029484071 abstract "One objective of this study was to determine the effects of N-hydroxy-2-acetylaminofluorene (N-OH-AAF) treatment on DNA synthesis in regenerating rat liver. Rats were subjected to a two-thirds hepatectomy followed 20 h later by i.p. injection of N-OH-AAF. 4 h after carcinogen injection, it was found that N-OH-AAF caused a dose-dependent inhibition of [3H]thymidine incorporation into liver DNA. This inhibition was followed by a gradual, but incomplete recovery beginning 28 h after carcinogen treatment. Radioimmunoassay of deoxyguanine-C8 adducts remaining in liver DNA indicated that the recovery began prior to detection of adduct removal. The second objective of the study was to determine the effects of DNA damage on the size distribution and elongation of nascent hepatocyte DNA. Hepatocytes, which have been shown to demonstrate a pattern of inhibition and subsequent recovery of DNA synthesis following UV irradiation similar to that seen in vivo upon treatment with N-OH-AAF (Zurlo and Yager, 1984), were cultured under conditions that promote replicative DNA synthesis. The size distribution of nascent DNA after UV irradiation was determined by pH step gradient alkaline elution analysis. [3H]Thymidine pulse times and subsequent chase times were adjusted to equalize amounts of DNA synthesis in control and UV-irradiated cells. The results show that UV irradiation caused a dose-dependent decrease in the size distribution of nascent DNA suggesting an inhibition of elongation. Pulse-chase studies revealed that subsequent joining of nascent chains in UV-irradiated hepatocytes occurred at a rate comparable to or faster than controls and that this could be inhibited by caffeine. The results obtained from both the in vivo and in vitro studies show that resumption of DNA synthesis and nascent strand elongation occur on damaged templates. These observations along with our previous studies demonstrating the ability of UV-irradiated hepatocytes to carry out enhanced reactivation of UV-irradiated herpes virus lend support to the idea that DNA damage leading to inhibition of DNA synthesis may induce SOS-type processes which if mutagenic may play a role in the initiation of carcinogenesis." @default.
• W2029484071 created "2016-06-24" @default.
• W2029484071 creator A5016404185 @default.
• W2029484071 creator A5045996317 @default.
• W2029484071 creator A5062921416 @default.
• W2029484071 creator A5089963590 @default.
• W2029484071 creator A5090128922 @default.
• W2029484071 date "1986-07-01" @default.
• W2029484071 modified "2023-09-28" @default.
• W2029484071 title "Effects of carcinogen treatment on rat liver DNA synthesis in vivo and on nascent DNA synthesis and elongation in cultured hepatocytes" @default.
• W2029484071 cites W1011552192 @default.
• W2029484071 cites W1490154674 @default.
• W2029484071 cites W1923728284 @default.
• W2029484071 cites W1964133885 @default.
• W2029484071 cites W1966730043 @default.
• W2029484071 cites W1974042440 @default.
• W2029484071 cites W1978223888 @default.
• W2029484071 cites W1979567658 @default.
• W2029484071 cites W1981218329 @default.
• W2029484071 cites W1984459901 @default.
• W2029484071 cites W1991331784 @default.
• W2029484071 cites W1996729627 @default.
• W2029484071 cites W2005381573 @default.
• W2029484071 cites W2013973825 @default.
• W2029484071 cites W2022037452 @default.
• W2029484071 cites W2030789354 @default.
• W2029484071 cites W2053610365 @default.
• W2029484071 cites W2060857138 @default.
• W2029484071 cites W2067582588 @default.
• W2029484071 cites W2070695934 @default.
• W2029484071 cites W2093377609 @default.
• W2029484071 cites W2166294284 @default.
• W2029484071 cites W951790091 @default.
• W2029484071 doi "https://doi.org/10.1016/0027-5107(86)90005-9" @default.
• W2029484071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3724770" @default.
• W2029484071 hasPublicationYear "1986" @default.
• W2029484071 type Work @default.
• W2029484071 sameAs 2029484071 @default.
• W2029484071 citedByCount "8" @default.
• W2029484071 countsByYear W20294840712017 @default.
• W2029484071 countsByYear W20294840712018 @default.
• W2029484071 crossrefType "journal-article" @default.
• W2029484071 hasAuthorship W2029484071A5016404185 @default.
• W2029484071 hasAuthorship W2029484071A5045996317 @default.
• W2029484071 hasAuthorship W2029484071A5062921416 @default.
• W2029484071 hasAuthorship W2029484071A5089963590 @default.
• W2029484071 hasAuthorship W2029484071A5090128922 @default.
• W2029484071 hasConcept C112950240 @default.
• W2029484071 hasConcept C114246631 @default.
• W2029484071 hasConcept C143425029 @default.
• W2029484071 hasConcept C153911025 @default.
• W2029484071 hasConcept C182420341 @default.
• W2029484071 hasConcept C185592680 @default.
• W2029484071 hasConcept C191897082 @default.
• W2029484071 hasConcept C192562407 @default.
• W2029484071 hasConcept C202751555 @default.
• W2029484071 hasConcept C207001950 @default.
• W2029484071 hasConcept C2776200302 @default.
• W2029484071 hasConcept C2777108182 @default.
• W2029484071 hasConcept C2779838395 @default.
• W2029484071 hasConcept C2781247443 @default.
• W2029484071 hasConcept C33947775 @default.
• W2029484071 hasConcept C54355233 @default.
• W2029484071 hasConcept C552990157 @default.
• W2029484071 hasConcept C55493867 @default.
• W2029484071 hasConcept C64241487 @default.
• W2029484071 hasConcept C86803240 @default.
• W2029484071 hasConcept C87644729 @default.
• W2029484071 hasConceptScore W2029484071C112950240 @default.
• W2029484071 hasConceptScore W2029484071C114246631 @default.
• W2029484071 hasConceptScore W2029484071C143425029 @default.
• W2029484071 hasConceptScore W2029484071C153911025 @default.
• W2029484071 hasConceptScore W2029484071C182420341 @default.
• W2029484071 hasConceptScore W2029484071C185592680 @default.
• W2029484071 hasConceptScore W2029484071C191897082 @default.
• W2029484071 hasConceptScore W2029484071C192562407 @default.
• W2029484071 hasConceptScore W2029484071C202751555 @default.
• W2029484071 hasConceptScore W2029484071C207001950 @default.
• W2029484071 hasConceptScore W2029484071C2776200302 @default.
• W2029484071 hasConceptScore W2029484071C2777108182 @default.
• W2029484071 hasConceptScore W2029484071C2779838395 @default.
• W2029484071 hasConceptScore W2029484071C2781247443 @default.
• W2029484071 hasConceptScore W2029484071C33947775 @default.
• W2029484071 hasConceptScore W2029484071C54355233 @default.
• W2029484071 hasConceptScore W2029484071C552990157 @default.
• W2029484071 hasConceptScore W2029484071C55493867 @default.
• W2029484071 hasConceptScore W2029484071C64241487 @default.
• W2029484071 hasConceptScore W2029484071C86803240 @default.
• W2029484071 hasConceptScore W2029484071C87644729 @default.
• W2029484071 hasIssue "2" @default.
• W2029484071 hasLocation W20294840711 @default.
• W2029484071 hasLocation W20294840712 @default.
• W2029484071 hasOpenAccess W2029484071 @default.
• W2029484071 hasPrimaryLocation W20294840711 @default.
• W2029484071 hasRelatedWork W1987363273 @default.
• W2029484071 hasRelatedWork W1996893063 @default.
• W2029484071 hasRelatedWork W2012315841 @default.
• W2029484071 hasRelatedWork W2029370209 @default.

• next