Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029484909> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2029484909 endingPage "45" @default.
- W2029484909 startingPage "43" @default.
- W2029484909 abstract "Gene therapy in human disease has expanded rapidly in recent years with the development of safer and more effective viral vectors, and presents a novel approach to the treatment of epilepsy. Studies in animals models have demonstrated that overexpression of inhibitory peptides can modify seizure threshold, prevent the development of epilepsy, and modify established epilepsy. More recently there has been a flurry of studies using optogenetics in which light-activated channels expressed in neurons can transiently change neuronal excitability on exposure to light, thereby enabling the development of closed loop systems to detect and stop seizure activity. The treatment of status epilepticus presents its own challenges. Because of both the delay in gene expression following transfection and also the necessity of using focal transfection, there are a limited number of situations in which gene therapy can be used in status epilepticus. One such condition is epilepsia partialis continua (EPC). We have used gene therapy in a model of EPC and have shown that we can cure the condition. Recent evidence suggesting that gene therapy targeting subcortical regions can modify generalized or more diffuse epilepsies, indicates that the range of situations in status epilepticus in which gene therapy could be used will expand." @default.
- W2029484909 created "2016-06-24" @default.
- W2029484909 creator A5007163256 @default.
- W2029484909 creator A5010996635 @default.
- W2029484909 creator A5022402604 @default.
- W2029484909 creator A5033570060 @default.
- W2029484909 creator A5081465083 @default.
- W2029484909 creator A5084558080 @default.
- W2029484909 date "2013-09-01" @default.
- W2029484909 modified "2023-10-18" @default.
- W2029484909 title "Gene therapy in status epilepticus" @default.
- W2029484909 cites W144183931 @default.
- W2029484909 cites W1520431725 @default.
- W2029484909 cites W1750845513 @default.
- W2029484909 cites W1996957734 @default.
- W2029484909 cites W1998165633 @default.
- W2029484909 cites W2008033906 @default.
- W2029484909 cites W2031457450 @default.
- W2029484909 cites W2033034517 @default.
- W2029484909 cites W2043485621 @default.
- W2029484909 cites W2047140970 @default.
- W2029484909 cites W2059898784 @default.
- W2029484909 cites W2090701557 @default.
- W2029484909 cites W2094365107 @default.
- W2029484909 cites W2134079336 @default.
- W2029484909 cites W2139928989 @default.
- W2029484909 cites W2156108573 @default.
- W2029484909 cites W2167237768 @default.
- W2029484909 cites W2171509705 @default.
- W2029484909 doi "https://doi.org/10.1111/epi.12275" @default.
- W2029484909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24001071" @default.
- W2029484909 hasPublicationYear "2013" @default.
- W2029484909 type Work @default.
- W2029484909 sameAs 2029484909 @default.
- W2029484909 citedByCount "10" @default.
- W2029484909 countsByYear W20294849092014 @default.
- W2029484909 countsByYear W20294849092015 @default.
- W2029484909 countsByYear W20294849092016 @default.
- W2029484909 countsByYear W20294849092017 @default.
- W2029484909 countsByYear W20294849092021 @default.
- W2029484909 crossrefType "journal-article" @default.
- W2029484909 hasAuthorship W2029484909A5007163256 @default.
- W2029484909 hasAuthorship W2029484909A5010996635 @default.
- W2029484909 hasAuthorship W2029484909A5022402604 @default.
- W2029484909 hasAuthorship W2029484909A5033570060 @default.
- W2029484909 hasAuthorship W2029484909A5081465083 @default.
- W2029484909 hasAuthorship W2029484909A5084558080 @default.
- W2029484909 hasBestOaLocation W20294849091 @default.
- W2029484909 hasConcept C104317684 @default.
- W2029484909 hasConcept C111599444 @default.
- W2029484909 hasConcept C169760540 @default.
- W2029484909 hasConcept C2777341932 @default.
- W2029484909 hasConcept C2778186239 @default.
- W2029484909 hasConcept C2779608047 @default.
- W2029484909 hasConcept C50738837 @default.
- W2029484909 hasConcept C54009773 @default.
- W2029484909 hasConcept C54355233 @default.
- W2029484909 hasConcept C57236427 @default.
- W2029484909 hasConcept C60644358 @default.
- W2029484909 hasConcept C71924100 @default.
- W2029484909 hasConcept C86803240 @default.
- W2029484909 hasConceptScore W2029484909C104317684 @default.
- W2029484909 hasConceptScore W2029484909C111599444 @default.
- W2029484909 hasConceptScore W2029484909C169760540 @default.
- W2029484909 hasConceptScore W2029484909C2777341932 @default.
- W2029484909 hasConceptScore W2029484909C2778186239 @default.
- W2029484909 hasConceptScore W2029484909C2779608047 @default.
- W2029484909 hasConceptScore W2029484909C50738837 @default.
- W2029484909 hasConceptScore W2029484909C54009773 @default.
- W2029484909 hasConceptScore W2029484909C54355233 @default.
- W2029484909 hasConceptScore W2029484909C57236427 @default.
- W2029484909 hasConceptScore W2029484909C60644358 @default.
- W2029484909 hasConceptScore W2029484909C71924100 @default.
- W2029484909 hasConceptScore W2029484909C86803240 @default.
- W2029484909 hasIssue "s6" @default.
- W2029484909 hasLocation W20294849091 @default.
- W2029484909 hasLocation W20294849092 @default.
- W2029484909 hasLocation W20294849093 @default.
- W2029484909 hasLocation W20294849094 @default.
- W2029484909 hasOpenAccess W2029484909 @default.
- W2029484909 hasPrimaryLocation W20294849091 @default.
- W2029484909 hasRelatedWork W1125507816 @default.
- W2029484909 hasRelatedWork W1507398508 @default.
- W2029484909 hasRelatedWork W1994308963 @default.
- W2029484909 hasRelatedWork W1995679204 @default.
- W2029484909 hasRelatedWork W2014281284 @default.
- W2029484909 hasRelatedWork W2024519277 @default.
- W2029484909 hasRelatedWork W2029484909 @default.
- W2029484909 hasRelatedWork W2063228636 @default.
- W2029484909 hasRelatedWork W2162771767 @default.
- W2029484909 hasRelatedWork W2274819798 @default.
- W2029484909 hasVolume "54" @default.
- W2029484909 isParatext "false" @default.
- W2029484909 isRetracted "false" @default.
- W2029484909 magId "2029484909" @default.
- W2029484909 workType "article" @default.