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- W2029488406 abstract "The changing pattern of sodium and potassium distribution during the first 72 hours after adrenal extirpation and the relation of this pattern to blood pressure was studied in a series of experiments in rats not provided with any form of maintenance therapy. Blood pressure declines significantly within 3 hours after adrenalectomy. This decline continues steeply over the next few hours but levels out within 24 hours to remain steady for the next two days. In a parallel time sequence, sodium and water move out of the extracellular phase while a smaller amount of potassium moves in. These changes can be clearly demonstrated even in the absence of the kidney. Apparently the effects of adrenalectomy are rapid in onset but are partially opposed by secondary factors which tend to establish a new equilibrium. WE HAVE recently demonstrated that agents which cause acute pressor or depressor effects in the rat and dog simultaneously cause transfers of sodium and water between cells and their environment (1, 2)." @default.
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- W2029488406 date "1958-03-01" @default.
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- W2029488406 title "THE EXTRARENAL EFFECT OF ADRENALECTOMY ON SODIUM AND POTASSIUM DISTRIBUTION IN THE RAT1" @default.
- W2029488406 doi "https://doi.org/10.1210/endo-62-3-259" @default.
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