Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029489831> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2029489831 endingPage "1191" @default.
- W2029489831 startingPage "1185" @default.
- W2029489831 abstract "Structural and electrophysiological changes of the atria occur with prolonged rapid rates; however, the effects of sustained atrial fibrillation (AF) on autonomic innervation of the atria are unknown. We hypothesized that electrophysiological remodeling from rapid atrial rates is accompanied by altered atrial autonomic innervation.Six dogs (paced group) underwent atrial pacing at 600 bpm; 9 dogs (control animals) were not paced. All paced dogs developed sustained AF by week 4 of pacing. All 15 animals underwent positron emission tomography imaging of the atria with [C-11] hydroxyephedrine (HED) to label sympathetic nerve terminals. HED retention in the atria was significantly greater in paced dogs compared with control animals (P=0.03). Tissue samples from the atrial appendages had a greater concentration of norepinephrine in paced animals than in control animals (P=0.01). The coefficient of variation of HED retention was also greater in paced animals (P=0.05) and was greater in the right atrium than in the left atrium (P=0.004). Epicardial activation maps of AF were obtained in the paced animals at baseline and with autonomic manipulation. Mean AF cycle length was longer in the right atrium (109.2+/-5 ms) than in the left atrium (85.8+/-5.5 ms) at baseline (P=0.005). AF cycle length did not vary significantly from baseline (97.6+/-13.4 ms) with stellate stimulation (100.5+/-6 ms) but lengthened with propranolol (107.5+/-6.1 ms, P=0.03).Rapid rates of AF produce a heterogeneous increase in atrial sympathetic innervation. These changes parallel disparate effects of rapid pacing-induced AF on atrial electrophysiology." @default.
- W2029489831 created "2016-06-24" @default.
- W2029489831 creator A5041238497 @default.
- W2029489831 creator A5042806179 @default.
- W2029489831 creator A5060374102 @default.
- W2029489831 creator A5073159182 @default.
- W2029489831 creator A5087796704 @default.
- W2029489831 creator A5090323803 @default.
- W2029489831 date "2000-03-14" @default.
- W2029489831 modified "2023-10-10" @default.
- W2029489831 title "Atrial Fibrillation Produced by Prolonged Rapid Atrial Pacing Is Associated With Heterogeneous Changes in Atrial Sympathetic Innervation" @default.
- W2029489831 cites W1979000106 @default.
- W2029489831 cites W1993338776 @default.
- W2029489831 cites W1996822291 @default.
- W2029489831 cites W2003219710 @default.
- W2029489831 cites W2013530317 @default.
- W2029489831 cites W2027709297 @default.
- W2029489831 cites W2046197269 @default.
- W2029489831 cites W2080026425 @default.
- W2029489831 cites W2151265492 @default.
- W2029489831 cites W2399565558 @default.
- W2029489831 doi "https://doi.org/10.1161/01.cir.101.10.1185" @default.
- W2029489831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10715267" @default.
- W2029489831 hasPublicationYear "2000" @default.
- W2029489831 type Work @default.
- W2029489831 sameAs 2029489831 @default.
- W2029489831 citedByCount "192" @default.
- W2029489831 countsByYear W20294898312012 @default.
- W2029489831 countsByYear W20294898312013 @default.
- W2029489831 countsByYear W20294898312014 @default.
- W2029489831 countsByYear W20294898312015 @default.
- W2029489831 countsByYear W20294898312016 @default.
- W2029489831 countsByYear W20294898312017 @default.
- W2029489831 countsByYear W20294898312018 @default.
- W2029489831 countsByYear W20294898312019 @default.
- W2029489831 countsByYear W20294898312020 @default.
- W2029489831 countsByYear W20294898312021 @default.
- W2029489831 countsByYear W20294898312022 @default.
- W2029489831 countsByYear W20294898312023 @default.
- W2029489831 crossrefType "journal-article" @default.
- W2029489831 hasAuthorship W2029489831A5041238497 @default.
- W2029489831 hasAuthorship W2029489831A5042806179 @default.
- W2029489831 hasAuthorship W2029489831A5060374102 @default.
- W2029489831 hasAuthorship W2029489831A5073159182 @default.
- W2029489831 hasAuthorship W2029489831A5087796704 @default.
- W2029489831 hasAuthorship W2029489831A5090323803 @default.
- W2029489831 hasBestOaLocation W20294898311 @default.
- W2029489831 hasConcept C114021368 @default.
- W2029489831 hasConcept C126322002 @default.
- W2029489831 hasConcept C164705383 @default.
- W2029489831 hasConcept C185263204 @default.
- W2029489831 hasConcept C2775914520 @default.
- W2029489831 hasConcept C2777372248 @default.
- W2029489831 hasConcept C2777953023 @default.
- W2029489831 hasConcept C2779161974 @default.
- W2029489831 hasConcept C2910272107 @default.
- W2029489831 hasConcept C42219234 @default.
- W2029489831 hasConcept C71924100 @default.
- W2029489831 hasConcept C84393581 @default.
- W2029489831 hasConceptScore W2029489831C114021368 @default.
- W2029489831 hasConceptScore W2029489831C126322002 @default.
- W2029489831 hasConceptScore W2029489831C164705383 @default.
- W2029489831 hasConceptScore W2029489831C185263204 @default.
- W2029489831 hasConceptScore W2029489831C2775914520 @default.
- W2029489831 hasConceptScore W2029489831C2777372248 @default.
- W2029489831 hasConceptScore W2029489831C2777953023 @default.
- W2029489831 hasConceptScore W2029489831C2779161974 @default.
- W2029489831 hasConceptScore W2029489831C2910272107 @default.
- W2029489831 hasConceptScore W2029489831C42219234 @default.
- W2029489831 hasConceptScore W2029489831C71924100 @default.
- W2029489831 hasConceptScore W2029489831C84393581 @default.
- W2029489831 hasIssue "10" @default.
- W2029489831 hasLocation W20294898311 @default.
- W2029489831 hasLocation W20294898312 @default.
- W2029489831 hasOpenAccess W2029489831 @default.
- W2029489831 hasPrimaryLocation W20294898311 @default.
- W2029489831 hasRelatedWork W2053292521 @default.
- W2029489831 hasRelatedWork W2062012785 @default.
- W2029489831 hasRelatedWork W2068326262 @default.
- W2029489831 hasRelatedWork W2126046382 @default.
- W2029489831 hasRelatedWork W2228399908 @default.
- W2029489831 hasRelatedWork W2385300224 @default.
- W2029489831 hasRelatedWork W2386756356 @default.
- W2029489831 hasRelatedWork W2414451984 @default.
- W2029489831 hasRelatedWork W3129788621 @default.
- W2029489831 hasRelatedWork W64458588 @default.
- W2029489831 hasVolume "101" @default.
- W2029489831 isParatext "false" @default.
- W2029489831 isRetracted "false" @default.
- W2029489831 magId "2029489831" @default.
- W2029489831 workType "article" @default.