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• W2029491370 abstract "HNF1α is a transcription factor that is expressed in pancreatic β-cells and mutations of the HNF1α gene cause a form of monogenic diabetes. To understand the role of HNF1α in pancreatic β-cells, we established the MIN6 β-cell line that stably expressed HNF1α-specific shRNA. Expression of the gene encoding hepatocyte growth factor (HGF) activator (Hgfac), a serine protease that efficiently activates HGF, was decreased in HNF1α KD-MIN6 cells. Down-regulation of Hgfac expression was also found in the islets of HNF1α (+/-) mice. Reporter gene analysis and the chromatin immunoprecipitation assay indicated that HNF1α directly regulates the expression of Hgfac in β-cells. It has been reported that HGF has an important influence on β-cell mass and β-cell function. Thus, HNF1α might regulate β-cell mass or function at least partly by modulating Hgfac expression." @default.
• W2029491370 created "2016-06-24" @default.
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• W2029491370 date "2012-08-01" @default.
• W2029491370 modified "2023-09-25" @default.
• W2029491370 title "Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells" @default.
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• W2029491370 doi "https://doi.org/10.1016/j.bbrc.2012.07.134" @default.
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