Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029493216> ?p ?o ?g. }
- W2029493216 endingPage "50" @default.
- W2029493216 startingPage "46" @default.
- W2029493216 abstract "Glycogen synthase kinase-3 (GSK-3), a multifunctional serine-threonine kinase, is an important regulator in numerous signaling pathways and processes including adult brain neurogenesis. GSK-3 (mal)functioning was implicated in many diseases, in particular neurological and behavioral disorders. We investigated the impact of altered levels of the GSK-3β isoform on hippocampal size, number of doublecortin-positive cells, and hippocampal-dependent behaviors. Both GSK-3β transgenic mice (GSK-3β[S9A] mice) and GSK-3β neuron-specific knockout (GSK-3βn−/−) mice, showed reduced size of the dentate gyrus (DG) and were impaired in three hippocampal-dependent, species-typical behavioral tasks: digging, marble burying and nest building. We further demonstrate that the number of differentiating, doublecortin-positive new neurons is reduced in GSK-3β[S9A] mice, but not in GSK-3βn−/− mice. We conclude that GSK-3β activity must be critically controlled to allow wild type-like volume of the dentate gyrus and for normal execution of hippocampal-dependent, species-typical behavior." @default.
- W2029493216 created "2016-06-24" @default.
- W2029493216 creator A5010975119 @default.
- W2029493216 creator A5052823748 @default.
- W2029493216 creator A5059540136 @default.
- W2029493216 creator A5068397286 @default.
- W2029493216 creator A5075390758 @default.
- W2029493216 creator A5080911401 @default.
- W2029493216 date "2013-07-01" @default.
- W2029493216 modified "2023-10-16" @default.
- W2029493216 title "Glycogen synthase kinase-3beta affects size of dentate gyrus and species-typical behavioral tasks in transgenic and knockout mice" @default.
- W2029493216 cites W1963600261 @default.
- W2029493216 cites W1964209299 @default.
- W2029493216 cites W1968461724 @default.
- W2029493216 cites W1970720793 @default.
- W2029493216 cites W1978342674 @default.
- W2029493216 cites W1981849971 @default.
- W2029493216 cites W1990098699 @default.
- W2029493216 cites W1993145412 @default.
- W2029493216 cites W1997376419 @default.
- W2029493216 cites W1998013040 @default.
- W2029493216 cites W2004586792 @default.
- W2029493216 cites W2005633501 @default.
- W2029493216 cites W2006090252 @default.
- W2029493216 cites W2023057825 @default.
- W2029493216 cites W2025565849 @default.
- W2029493216 cites W2028616351 @default.
- W2029493216 cites W2036684788 @default.
- W2029493216 cites W2046148144 @default.
- W2029493216 cites W2051173215 @default.
- W2029493216 cites W2060146392 @default.
- W2029493216 cites W2079472896 @default.
- W2029493216 cites W2088135834 @default.
- W2029493216 cites W2093802594 @default.
- W2029493216 cites W2105382539 @default.
- W2029493216 cites W2121878996 @default.
- W2029493216 cites W2139075903 @default.
- W2029493216 cites W2139553041 @default.
- W2029493216 cites W2146316688 @default.
- W2029493216 cites W2153779995 @default.
- W2029493216 cites W2154443522 @default.
- W2029493216 cites W2164173275 @default.
- W2029493216 cites W2167928721 @default.
- W2029493216 cites W2168024183 @default.
- W2029493216 cites W2312253285 @default.
- W2029493216 cites W2793634050 @default.
- W2029493216 doi "https://doi.org/10.1016/j.bbr.2013.03.045" @default.
- W2029493216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23570858" @default.
- W2029493216 hasPublicationYear "2013" @default.
- W2029493216 type Work @default.
- W2029493216 sameAs 2029493216 @default.
- W2029493216 citedByCount "24" @default.
- W2029493216 countsByYear W20294932162014 @default.
- W2029493216 countsByYear W20294932162015 @default.
- W2029493216 countsByYear W20294932162016 @default.
- W2029493216 countsByYear W20294932162017 @default.
- W2029493216 countsByYear W20294932162018 @default.
- W2029493216 countsByYear W20294932162019 @default.
- W2029493216 countsByYear W20294932162021 @default.
- W2029493216 countsByYear W20294932162022 @default.
- W2029493216 countsByYear W20294932162023 @default.
- W2029493216 crossrefType "journal-article" @default.
- W2029493216 hasAuthorship W2029493216A5010975119 @default.
- W2029493216 hasAuthorship W2029493216A5052823748 @default.
- W2029493216 hasAuthorship W2029493216A5059540136 @default.
- W2029493216 hasAuthorship W2029493216A5068397286 @default.
- W2029493216 hasAuthorship W2029493216A5075390758 @default.
- W2029493216 hasAuthorship W2029493216A5080911401 @default.
- W2029493216 hasConcept C102230213 @default.
- W2029493216 hasConcept C104317684 @default.
- W2029493216 hasConcept C104629339 @default.
- W2029493216 hasConcept C11960822 @default.
- W2029493216 hasConcept C126322002 @default.
- W2029493216 hasConcept C134018914 @default.
- W2029493216 hasConcept C141035611 @default.
- W2029493216 hasConcept C148762608 @default.
- W2029493216 hasConcept C169760540 @default.
- W2029493216 hasConcept C170493617 @default.
- W2029493216 hasConcept C182704531 @default.
- W2029493216 hasConcept C182996813 @default.
- W2029493216 hasConcept C184235292 @default.
- W2029493216 hasConcept C192118531 @default.
- W2029493216 hasConcept C2776464000 @default.
- W2029493216 hasConcept C2781461022 @default.
- W2029493216 hasConcept C4746552 @default.
- W2029493216 hasConcept C55493867 @default.
- W2029493216 hasConcept C71924100 @default.
- W2029493216 hasConcept C86803240 @default.
- W2029493216 hasConcept C95444343 @default.
- W2029493216 hasConceptScore W2029493216C102230213 @default.
- W2029493216 hasConceptScore W2029493216C104317684 @default.
- W2029493216 hasConceptScore W2029493216C104629339 @default.
- W2029493216 hasConceptScore W2029493216C11960822 @default.
- W2029493216 hasConceptScore W2029493216C126322002 @default.
- W2029493216 hasConceptScore W2029493216C134018914 @default.
- W2029493216 hasConceptScore W2029493216C141035611 @default.
- W2029493216 hasConceptScore W2029493216C148762608 @default.
- W2029493216 hasConceptScore W2029493216C169760540 @default.