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• W2029497762 startingPage "3981" @default.
• W2029497762 abstract "Entorhinal cortex (ERC) volume in adults with mild cognitive impairment has been shown to predict prodromal Alzheimer's disease (AD). Likewise, neuronal loss in ERC has been associated with AD, but not with normal aging. Because ERC is part of a major pathway modulating input to the hippocampus, structural changes there may result in changes to cognitive performance and functional brain activity during memory tasks. In 32 cognitively intact older adults, we examined the relationship between left ERC thickness and functional magnetic resonance imaging (fMRI) activity during an associative verbal memory task. This task has been shown previously to activate regions that are sensitive to aging and AD risk. ERC was manually defined on native space, high resolution, oblique coronal MRI scans. Subjects having thicker left ERC showed greater activation in anterior cingulate and medial frontal regions during memory retrieval, but not encoding. This result was independent of hippocampal volume. Anterior cingulate cortex is directly connected to ERC, and is, along with medial frontal cortex, implicated in error detection, which is impaired in AD. Our results suggest that in healthy older adults, processes that engage frontal regions during memory retrieval are related to ERC structure." @default.
• W2029497762 created "2016-06-24" @default.
• W2029497762 creator A5001598199 @default.
• W2029497762 creator A5022622401 @default.
• W2029497762 creator A5037452444 @default.
• W2029497762 date "2009-06-08" @default.
• W2029497762 modified "2023-09-25" @default.
• W2029497762 title "Entorhinal cortex structure and functional MRI response during an associative verbal memory task" @default.
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• W2029497762 doi "https://doi.org/10.1002/hbm.20823" @default.
• W2029497762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2787760" @default.
• W2029497762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19507155" @default.
• W2029497762 hasPublicationYear "2009" @default.
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