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- W2029498457 abstract "The Default Mode Network (DMN) is one of the cognitive networks that is metabolically active when subjects are not engaged in a specified cognitive task. Brain regions that constitute the DMN include the posterior cingulate, lateral parietal, and medial frontal cortex. Along with medial temporal lobe structures, some of these regions are also involved with episodic memory function. These same anatomic areas undergo preferential amyloid plaque formation in AD, and therefore the ability to detect alterations in this network has significant implications for understanding and detecting functional brain changes in these individuals. We scanned 16 cognitively normal elderly (CN), 16 amnestic MCI (aMCI), and 14 probable AD matched for age and education at 3T. Subjects were instructed to keep their eyes closed. Resting functional MR time-series were preprocessed using SPM5, which included slice timing correction, motion correction and normalization to the MNI_EPI template. Data were smoothed with an 8mm kernel. The preprocessed data were separated into independent components using FSL MELODIC. We used a template matching procedure to identify the DMN for each subject that was then entered into one- and two-sample t-tests. The CN group showed activation in areas matching the DMN including a large region in the posterior cingulate, lateral inferior parietal lobe bilaterally, and medial frontal cortex. The aMCI group showed activation in these same regions. The AD group showed more diffuse activation that included the posterior cingulate, lateral inferior parietal lobe bilaterally, thalamus, and spotty areas in the dorsolateral prefrontal cortex. The CN vs. aMCI comparison revealed greater activation in the CN group, primarily in the posterior cingulate (t = 2.77, p < .05, uncorrected; 22 voxels). The CN vs. AD comparison showed greater activation in the CN group in a substantially larger region encompassing the posterior cingulate (t = 3.43, p < .05, uncorrected; 764 voxels) and the right lateral parietal lobe (t = 3.11, p < .05, uncorrected, 43 voxels). Our results provide evidence for 1) disruption of DMN circuitry in the posterior cingulate in aMCI, and to a greater extent in AD, 2) potential of DMN changes as a biomarker for early detection of AD." @default.
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- W2029498457 date "2009-07-01" @default.
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- W2029498457 title "P2-024: Examination of default mode network activity along the cognitive continuum: Normal aging, MCI and AD" @default.
- W2029498457 doi "https://doi.org/10.1016/j.jalz.2009.04.333" @default.
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