FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029498478> ?p ?o ?g. }

• W2029498478 endingPage "169" @default.
• W2029498478 startingPage "164" @default.
• W2029498478 abstract "Inorganic arsenic is enzymatically methylated; hence, its ingestion results in exposure to the parent compound and various methylated arsenicals. Both experimental and epidemiological evidences suggest that some of the adverse health effects associated with chronic exposure to inorganic arsenic may be mediated by these methylated metabolites. If iAs methylation is an activation process, then the phenotype for inorganic arsenic methylation may determine risk associated with exposure to this metalloid. We examined inorganic arsenic methylation phenotypes and arsenic (+3 oxidation state) methyltransferase genotypes in four species: three that methylate inorganic arsenic (human (Homo sapiens), rat (Rattus norwegicus), and mouse (Mus musculus)) and one that does not methylate inorganic arsenic (chimpanzee, Pan troglodytes). The predicted protein products from arsenic (+3 oxidation state) methyltransferase are similar in size for rat (369 amino acid residues), mouse (376 residues), and human (375 residues). By comparison, a 275-nucleotide deletion beginning at nucleotide 612 in the chimpanzee gene sequence causes a frameshift that leads to a nonsense mutation for a premature stop codon after amino acid 205. The null phenotype for inorganic arsenic methylation in the chimpanzee is likely due to the deletion in the gene for arsenic (+3 oxidation state) methyltransferase that yields an inactive truncated protein. This lineage-specific loss of function caused by the deletion event must have occurred in the Pan lineage after Homo-Pan divergence about 5 million years ago." @default.
• W2029498478 created "2016-06-24" @default.
• W2029498478 creator A5008435804 @default.
• W2029498478 creator A5017061461 @default.
• W2029498478 creator A5017143150 @default.
• W2029498478 creator A5044570724 @default.
• W2029498478 creator A5059862147 @default.
• W2029498478 creator A5072977251 @default.
• W2029498478 date "2005-04-01" @default.
• W2029498478 modified "2023-10-18" @default.
• W2029498478 title "Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype" @default.
• W2029498478 cites W1505133202 @default.
• W2029498478 cites W1745280408 @default.
• W2029498478 cites W1964478998 @default.
• W2029498478 cites W1976068701 @default.
• W2029498478 cites W1987827766 @default.
• W2029498478 cites W2008229855 @default.
• W2029498478 cites W2008491894 @default.
• W2029498478 cites W2011501030 @default.
• W2029498478 cites W2026258231 @default.
• W2029498478 cites W2029583268 @default.
• W2029498478 cites W2049089966 @default.
• W2029498478 cites W2053325510 @default.
• W2029498478 cites W2065170814 @default.
• W2029498478 cites W2074495192 @default.
• W2029498478 cites W2076799720 @default.
• W2029498478 cites W2079987670 @default.
• W2029498478 cites W2085033409 @default.
• W2029498478 cites W2106882534 @default.
• W2029498478 cites W2110973918 @default.
• W2029498478 cites W2129911411 @default.
• W2029498478 cites W2140514445 @default.
• W2029498478 cites W2151065392 @default.
• W2029498478 cites W2161552991 @default.
• W2029498478 cites W2167586301 @default.
• W2029498478 doi "https://doi.org/10.1016/j.taap.2004.12.002" @default.
• W2029498478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15808521" @default.
• W2029498478 hasPublicationYear "2005" @default.
• W2029498478 type Work @default.
• W2029498478 sameAs 2029498478 @default.
• W2029498478 citedByCount "59" @default.
• W2029498478 countsByYear W20294984782012 @default.
• W2029498478 countsByYear W20294984782013 @default.
• W2029498478 countsByYear W20294984782014 @default.
• W2029498478 countsByYear W20294984782015 @default.
• W2029498478 countsByYear W20294984782016 @default.
• W2029498478 countsByYear W20294984782017 @default.
• W2029498478 countsByYear W20294984782018 @default.
• W2029498478 countsByYear W20294984782020 @default.
• W2029498478 countsByYear W20294984782021 @default.
• W2029498478 countsByYear W20294984782022 @default.
• W2029498478 crossrefType "journal-article" @default.
• W2029498478 hasAuthorship W2029498478A5008435804 @default.
• W2029498478 hasAuthorship W2029498478A5017061461 @default.
• W2029498478 hasAuthorship W2029498478A5017143150 @default.
• W2029498478 hasAuthorship W2029498478A5044570724 @default.
• W2029498478 hasAuthorship W2029498478A5059862147 @default.
• W2029498478 hasAuthorship W2029498478A5072977251 @default.
• W2029498478 hasBestOaLocation W20294984782 @default.
• W2029498478 hasConcept C104317684 @default.
• W2029498478 hasConcept C127716648 @default.
• W2029498478 hasConcept C172507514 @default.
• W2029498478 hasConcept C178790620 @default.
• W2029498478 hasConcept C185592680 @default.
• W2029498478 hasConcept C33288867 @default.
• W2029498478 hasConcept C502230775 @default.
• W2029498478 hasConcept C54355233 @default.
• W2029498478 hasConcept C55493867 @default.
• W2029498478 hasConcept C86803240 @default.
• W2029498478 hasConcept C91965660 @default.
• W2029498478 hasConceptScore W2029498478C104317684 @default.
• W2029498478 hasConceptScore W2029498478C127716648 @default.
• W2029498478 hasConceptScore W2029498478C172507514 @default.
• W2029498478 hasConceptScore W2029498478C178790620 @default.
• W2029498478 hasConceptScore W2029498478C185592680 @default.
• W2029498478 hasConceptScore W2029498478C33288867 @default.
• W2029498478 hasConceptScore W2029498478C502230775 @default.
• W2029498478 hasConceptScore W2029498478C54355233 @default.
• W2029498478 hasConceptScore W2029498478C55493867 @default.
• W2029498478 hasConceptScore W2029498478C86803240 @default.
• W2029498478 hasConceptScore W2029498478C91965660 @default.
• W2029498478 hasIssue "2" @default.
• W2029498478 hasLocation W20294984781 @default.
• W2029498478 hasLocation W20294984782 @default.
• W2029498478 hasLocation W20294984783 @default.
• W2029498478 hasOpenAccess W2029498478 @default.
• W2029498478 hasPrimaryLocation W20294984781 @default.
• W2029498478 hasRelatedWork W1765510456 @default.
• W2029498478 hasRelatedWork W2027719726 @default.
• W2029498478 hasRelatedWork W2048747342 @default.
• W2029498478 hasRelatedWork W2114643988 @default.
• W2029498478 hasRelatedWork W2135699074 @default.
• W2029498478 hasRelatedWork W2169935164 @default.
• W2029498478 hasRelatedWork W2883290458 @default.
• W2029498478 hasRelatedWork W2888439409 @default.
• W2029498478 hasRelatedWork W4281762279 @default.
• W2029498478 hasRelatedWork W4386393025 @default.
• W2029498478 hasVolume "204" @default.

• next