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• W2029505327 endingPage "7935" @default.
• W2029505327 startingPage "7929" @default.
• W2029505327 abstract "Activin, a member of the transforming growth factor β (TGF-β) superfamily, signals through a heteromeric complex of type I and type II serine-threonine kinase receptors. The two activin type I receptors previously identified, ALK-2 (ActR-I) and ALK-4 (ActR-IB), have distinct effects on gene expression, differentiation and morphogenesis in the <i>Xenopus</i> animal cap assay. ALK-4 reproduces the effects of activin treatment including the dose-dependent induction of progressively more dorso-anterior mesodermal and endodermal markers, whereas ALK-2 induces only ventral mesodermal markers and counteracts the effects of ALK-4. To identify regions of the receptors that determine signaling specificity we have generated chimeras of the constitutively active ALK-2 and ALK-4 receptors (termed ALK-2* and ALK-4*). The effects of these chimeric receptors on gene expression and morphogenetic movements implicate the loop between kinase subdomains IV and V in mediating the strong dorsal gene-inducing properties of ALK-4*; when the seven amino acids comprising this loop are transferred from ALK-4* to ALK-2*, the resulting chimeric receptor is capable of inducing the expression of dorsal-specific genes. In contrast, when the equivalent region of ALK-2* is transferred to the ALK-4* backbone it cannot effectively counteract the dorsalizing effects of ALK-4*, suggesting that other regions of type I receptors are also involved in determining signal specificity." @default.
• W2029505327 created "2016-06-24" @default.
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• W2029505327 date "1999-03-01" @default.
• W2029505327 modified "2023-09-30" @default.
• W2029505327 title "A Short Loop on the ALK-2 and ALK-4 Activin Receptors Regulates Signaling Specificity but Cannot Account for All Their Effects on EarlyXenopus Development" @default.
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• W2029505327 doi "https://doi.org/10.1074/jbc.274.12.7929" @default.
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