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- W2029505786 abstract "Heterologous anti-mouse δ chain has been shown to induce T-independent polyclonal B cell proliferation by 24 h after injection into mice and a T-dependent polyclonal increase in the number of IgG-secreting cells in spleen and lymph nodes 6 days after injection. The effect of anti-δ on germinal center cells has been difficult to determine, however, since anti-δ-induced blast transformation of mantle zone cells makes it difficult to distinguish these cells from germinal center cells. To clarify the effect of anti-δ on germinal centers, we stained lymph node sections from control and anti-δ-injected mice with peanut agglutinin conjugated to horseradish peroxidase which clearly differentiates the germinal center cells from other large and small lymphoid cells. For the first 5 days after i.v. injection of goat anti-mouse δ, the germinal center volumes did not differ significantly from those of mice injected with control antibodies. On days 6 and 7 after injection, the lymph node germinal center volumes of anti-δ-treated mice increased on average over 10-fold as compared to those of mice injected with an equal amount of control antibody. Thus, while anti-δ antibody directly induced blastogenesis of mantle layer B cells, it appears to have little direct effect on germinal center cells. In contrast, rapid germinal center development is seen in anti-δ-injected mice during the T-dependent phase of B cell activation and occurs simultaneously with the appearance of large numbers of IgG-secreting cells." @default.
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- W2029505786 date "1984-01-01" @default.
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- W2029505786 title "Polyclonal activation of the murine immune system by an antibody to IgD V. Effect on germinal centers" @default.
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- W2029505786 doi "https://doi.org/10.1002/eji.1830140810" @default.
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