FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029508960> ?p ?o ?g. }

• W2029508960 endingPage "30" @default.
• W2029508960 startingPage "23" @default.
• W2029508960 abstract "The effect of Tyr-D-Arg-Phe-Sar (TAPS), a mu-selective tetrapeptide analog of dermorphin, was studied in the rat both in vitro, using slices of the locus coeruleus, and in vivo, after microinjection into the locus coeruleus. In electrophysiological studies, TAPS (1-100 nM) was able to inhibit spontaneous firing, cause hyperpolarization of the membrane potential and reduce the input resistance of neurons of the locus coeruleus, suggesting that there was an effect on the potassium channels. Based on the inhibition of the spontaneous firing rate, the average IC50 for TAPS was calculated to be 1.9 nM, a value lower than that reported for dermorphin or morphine. The TAPS-induced effects were antagonized by naloxone, with a dissociation equilibrium constant of 1.96 +/- 0.14 nM. The results indicate that TAPS binds to mu-opioid receptors on the cell membrane of neurons of the locus coeruleus to cause its inhibitory actions. In behavioral study, TAPS was microinjected bilaterally via chronically implanted cannulae into the locus coeruleus of non-anesthetized rats and its effects on locomotor activity determined. TAPS, at concentrations of 1 microM and 10 microM, but not of 0.1 microM, induced hypolocomotion/sedation and the effect was significantly reversed by naloxone (5 mg/kg i.p.). Taken together, these data suggest that TAPS has an inhibitory effect on neurons of the locus coeruleus and produces hypolocomotive/sedative effects in vivo." @default.
• W2029508960 created "2016-06-24" @default.
• W2029508960 creator A5007462766 @default.
• W2029508960 creator A5054348057 @default.
• W2029508960 creator A5087597869 @default.
• W2029508960 date "1998-06-01" @default.
• W2029508960 modified "2023-09-23" @default.
• W2029508960 title "Electrophysiological and behavioral effects of Tyr-d-Arg-Phe-Sar on locus coeruleus neurons of the rat" @default.
• W2029508960 cites W1617932235 @default.
• W2029508960 cites W1965166997 @default.
• W2029508960 cites W1965810471 @default.
• W2029508960 cites W1966067134 @default.
• W2029508960 cites W1969929310 @default.
• W2029508960 cites W1970756106 @default.
• W2029508960 cites W1976288735 @default.
• W2029508960 cites W1978674173 @default.
• W2029508960 cites W1979293468 @default.
• W2029508960 cites W1986807641 @default.
• W2029508960 cites W1989641582 @default.
• W2029508960 cites W1997386700 @default.
• W2029508960 cites W2000818074 @default.
• W2029508960 cites W2009052530 @default.
• W2029508960 cites W2012040575 @default.
• W2029508960 cites W2015766640 @default.
• W2029508960 cites W2018424091 @default.
• W2029508960 cites W2024584487 @default.
• W2029508960 cites W2030563317 @default.
• W2029508960 cites W2035640312 @default.
• W2029508960 cites W2038658131 @default.
• W2029508960 cites W2040962697 @default.
• W2029508960 cites W2044142012 @default.
• W2029508960 cites W2046371281 @default.
• W2029508960 cites W2048538659 @default.
• W2029508960 cites W2050168291 @default.
• W2029508960 cites W2059819928 @default.
• W2029508960 cites W2062745050 @default.
• W2029508960 cites W2071953249 @default.
• W2029508960 cites W2084924586 @default.
• W2029508960 cites W2087674088 @default.
• W2029508960 cites W2091196978 @default.
• W2029508960 cites W2136224855 @default.
• W2029508960 cites W2140257707 @default.
• W2029508960 cites W2173726217 @default.
• W2029508960 doi "https://doi.org/10.1016/s0014-2999(98)00296-9" @default.
• W2029508960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9698201" @default.
• W2029508960 hasPublicationYear "1998" @default.
• W2029508960 type Work @default.
• W2029508960 sameAs 2029508960 @default.
• W2029508960 citedByCount "14" @default.
• W2029508960 countsByYear W20295089602014 @default.
• W2029508960 countsByYear W20295089602023 @default.
• W2029508960 crossrefType "journal-article" @default.
• W2029508960 hasAuthorship W2029508960A5007462766 @default.
• W2029508960 hasAuthorship W2029508960A5054348057 @default.
• W2029508960 hasAuthorship W2029508960A5087597869 @default.
• W2029508960 hasConcept C112592302 @default.
• W2029508960 hasConcept C126322002 @default.
• W2029508960 hasConcept C131453863 @default.
• W2029508960 hasConcept C134018914 @default.
• W2029508960 hasConcept C169760540 @default.
• W2029508960 hasConcept C170493617 @default.
• W2029508960 hasConcept C17077164 @default.
• W2029508960 hasConcept C185263204 @default.
• W2029508960 hasConcept C185592680 @default.
• W2029508960 hasConcept C2778468602 @default.
• W2029508960 hasConcept C2778750930 @default.
• W2029508960 hasConcept C2778981110 @default.
• W2029508960 hasConcept C2781063702 @default.
• W2029508960 hasConcept C529278444 @default.
• W2029508960 hasConcept C55493867 @default.
• W2029508960 hasConcept C66974803 @default.
• W2029508960 hasConcept C71240020 @default.
• W2029508960 hasConcept C71924100 @default.
• W2029508960 hasConcept C86803240 @default.
• W2029508960 hasConcept C88016717 @default.
• W2029508960 hasConcept C98274493 @default.
• W2029508960 hasConceptScore W2029508960C112592302 @default.
• W2029508960 hasConceptScore W2029508960C126322002 @default.
• W2029508960 hasConceptScore W2029508960C131453863 @default.
• W2029508960 hasConceptScore W2029508960C134018914 @default.
• W2029508960 hasConceptScore W2029508960C169760540 @default.
• W2029508960 hasConceptScore W2029508960C170493617 @default.
• W2029508960 hasConceptScore W2029508960C17077164 @default.
• W2029508960 hasConceptScore W2029508960C185263204 @default.
• W2029508960 hasConceptScore W2029508960C185592680 @default.
• W2029508960 hasConceptScore W2029508960C2778468602 @default.
• W2029508960 hasConceptScore W2029508960C2778750930 @default.
• W2029508960 hasConceptScore W2029508960C2778981110 @default.
• W2029508960 hasConceptScore W2029508960C2781063702 @default.
• W2029508960 hasConceptScore W2029508960C529278444 @default.
• W2029508960 hasConceptScore W2029508960C55493867 @default.
• W2029508960 hasConceptScore W2029508960C66974803 @default.
• W2029508960 hasConceptScore W2029508960C71240020 @default.
• W2029508960 hasConceptScore W2029508960C71924100 @default.
• W2029508960 hasConceptScore W2029508960C86803240 @default.
• W2029508960 hasConceptScore W2029508960C88016717 @default.
• W2029508960 hasConceptScore W2029508960C98274493 @default.
• W2029508960 hasIssue "1" @default.

• next