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- W2029512671 abstract "From a smokers clinic we selected 51 cigarette smokers who had normal FEV1.0. We then studied them in detail with the MRC questionnaire and tests of pulmonary function. Tests included measurements of RV/TLC, specific conductance, the flow-volume curve, N2 washout, dynamic compliance at a number of breathing frequencies (CDYN) closing volume and a new test which examined flow-dependent changes in the distribution of an inhaled bolus of 133Xe (ΔXe). Twenty-eight subjects demonstrated small airways disease as defined by a normal FEV1.0 and a decrease in CDYN with increased breathing frequency. Abnormalities in the flow-volume curve, of specific conductance and RV/TLC were also present in some subjects, but the sensitivity of these tests was less than that of frequency dependence of CDYN. Thirty-two subjects demonstrated abnormally large closing volumes and 32 were abnormal by the Xe tests; the results of these two studies correlated well with frequency induced changes in CDYN. Abnormalities in these tests, however, did not correlate well with positivity of the MRC questionnaire." @default.
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- W2029512671 date "1973-04-01" @default.
- W2029512671 modified "2023-09-30" @default.
- W2029512671 title "Reversible Small Airway Obstruction Associated with Cigarette Smoking" @default.
- W2029512671 doi "https://doi.org/10.1378/chest.63.4_supplement.31s" @default.
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