FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029523356> ?p ?o ?g. }

• W2029523356 endingPage "667" @default.
• W2029523356 startingPage "662" @default.
• W2029523356 abstract "TNF-α plays critical roles in bone-resorbing diseases, such as rheumatoid arthritis. Recent evidence suggests that thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor γ agonists, have anti-inflammatory effects. The aim of this study was to evaluate the effect of TZDs on the TNF-α-mediated osteoclastogenesis of osteoclast precursor cells. TNF-α treatment of RAW264.7 murine macrophages or mouse bone marrow cells induced significant multinuclear osteoclast formation, and these differentiated osteoclast cells possessed bone-resorbing activity. The TZD drugs, rosiglitazone and pioglitazone, significantly inhibited TNF-α-induced osteoclast differentiation from both cell types and subsequent bone resorption. Reverse transcriptase-polymerase chain reaction, reporter gene assays, and Western blot results revealed that TZD treatment significantly suppressed NFATc1 expression. Moreover, GW9662 (a peroxisome proliferator-activated receptor γ antagonist) prevented the inhibitory effect of TZDs on NFATc1 expression and osteoclast differentiation. In summary, our results demonstrate that TZDs inhibit TNF-α-mediated osteoclast differentiation by downregulation of NFATc1 expression. This observation increases the therapeutic applications of TZDs in inflammatory bone-resorbing diseases." @default.
• W2029523356 created "2016-06-24" @default.
• W2029523356 creator A5001793326 @default.
• W2029523356 creator A5023298216 @default.
• W2029523356 date "2010-06-01" @default.
• W2029523356 modified "2023-10-16" @default.
• W2029523356 title "THIAZOLIDINEDIONES INHIBIT TNF-α-MEDIATED OSTEOCLAST DIFFERENTIATION OF RAW264.7 MACROPHAGES AND MOUSE BONE MARROW CELLS THROUGH DOWNREGULATION OF NFATc1" @default.
• W2029523356 cites W1902846622 @default.
• W2029523356 cites W1974618081 @default.
• W2029523356 cites W1975505424 @default.
• W2029523356 cites W1993265910 @default.
• W2029523356 cites W1995580612 @default.
• W2029523356 cites W2002786747 @default.
• W2029523356 cites W2006831045 @default.
• W2029523356 cites W2008528726 @default.
• W2029523356 cites W2017372504 @default.
• W2029523356 cites W2031504111 @default.
• W2029523356 cites W2040565048 @default.
• W2029523356 cites W2042570856 @default.
• W2029523356 cites W2046833545 @default.
• W2029523356 cites W2055224067 @default.
• W2029523356 cites W2056260385 @default.
• W2029523356 cites W2059050180 @default.
• W2029523356 cites W2059895383 @default.
• W2029523356 cites W2060870390 @default.
• W2029523356 cites W2073231031 @default.
• W2029523356 cites W2077779110 @default.
• W2029523356 cites W2085853581 @default.
• W2029523356 cites W2087092773 @default.
• W2029523356 cites W2091673549 @default.
• W2029523356 cites W2093588246 @default.
• W2029523356 cites W2105700895 @default.
• W2029523356 cites W2106171259 @default.
• W2029523356 cites W2142961694 @default.
• W2029523356 cites W2143813009 @default.
• W2029523356 cites W2148403865 @default.
• W2029523356 cites W2167908723 @default.
• W2029523356 cites W2168143492 @default.
• W2029523356 cites W2171533490 @default.
• W2029523356 cites W4237205057 @default.
• W2029523356 doi "https://doi.org/10.1097/shk.0b013e3181cc0738" @default.
• W2029523356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19953004" @default.
• W2029523356 hasPublicationYear "2010" @default.
• W2029523356 type Work @default.
• W2029523356 sameAs 2029523356 @default.
• W2029523356 citedByCount "21" @default.
• W2029523356 countsByYear W20295233562013 @default.
• W2029523356 countsByYear W20295233562014 @default.
• W2029523356 countsByYear W20295233562015 @default.
• W2029523356 countsByYear W20295233562016 @default.
• W2029523356 countsByYear W20295233562017 @default.
• W2029523356 countsByYear W20295233562018 @default.
• W2029523356 countsByYear W20295233562021 @default.
• W2029523356 countsByYear W20295233562022 @default.
• W2029523356 crossrefType "journal-article" @default.
• W2029523356 hasAuthorship W2029523356A5001793326 @default.
• W2029523356 hasAuthorship W2029523356A5023298216 @default.
• W2029523356 hasBestOaLocation W20295233561 @default.
• W2029523356 hasConcept C104317684 @default.
• W2029523356 hasConcept C126322002 @default.
• W2029523356 hasConcept C127561419 @default.
• W2029523356 hasConcept C134018914 @default.
• W2029523356 hasConcept C170493617 @default.
• W2029523356 hasConcept C17991360 @default.
• W2029523356 hasConcept C185592680 @default.
• W2029523356 hasConcept C2776033226 @default.
• W2029523356 hasConcept C2777180221 @default.
• W2029523356 hasConcept C2778384471 @default.
• W2029523356 hasConcept C2780007613 @default.
• W2029523356 hasConcept C2780152017 @default.
• W2029523356 hasConcept C502942594 @default.
• W2029523356 hasConcept C55493867 @default.
• W2029523356 hasConcept C555293320 @default.
• W2029523356 hasConcept C673006 @default.
• W2029523356 hasConcept C71924100 @default.
• W2029523356 hasConcept C86803240 @default.
• W2029523356 hasConcept C95444343 @default.
• W2029523356 hasConceptScore W2029523356C104317684 @default.
• W2029523356 hasConceptScore W2029523356C126322002 @default.
• W2029523356 hasConceptScore W2029523356C127561419 @default.
• W2029523356 hasConceptScore W2029523356C134018914 @default.
• W2029523356 hasConceptScore W2029523356C170493617 @default.
• W2029523356 hasConceptScore W2029523356C17991360 @default.
• W2029523356 hasConceptScore W2029523356C185592680 @default.
• W2029523356 hasConceptScore W2029523356C2776033226 @default.
• W2029523356 hasConceptScore W2029523356C2777180221 @default.
• W2029523356 hasConceptScore W2029523356C2778384471 @default.
• W2029523356 hasConceptScore W2029523356C2780007613 @default.
• W2029523356 hasConceptScore W2029523356C2780152017 @default.
• W2029523356 hasConceptScore W2029523356C502942594 @default.
• W2029523356 hasConceptScore W2029523356C55493867 @default.
• W2029523356 hasConceptScore W2029523356C555293320 @default.
• W2029523356 hasConceptScore W2029523356C673006 @default.
• W2029523356 hasConceptScore W2029523356C71924100 @default.
• W2029523356 hasConceptScore W2029523356C86803240 @default.
• W2029523356 hasConceptScore W2029523356C95444343 @default.
• W2029523356 hasIssue "6" @default.
• W2029523356 hasLocation W20295233561 @default.

• next