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- W2029541438 abstract "Abstract Silica-based chromatography columns can be effectively regenerated with sodium hydroxide solutions containing millimolar levels of aluminum salts. The presence of aluminum ions in the caustic wash significantly reduced and in some cases virtually eliminated silica dissolution from silica-based anion-exchange columns. Wide-pore polymer coated anion-exchange packings for protein separations were washed in excess of 100 cycles with 0.1 M and 0.5 M sodium hydroxide containing aluminum nitrate with no detectable deterioration of the column bed or chromatographic performance. The protection results from incorporation of aluminosilicate sites on the silica support surface beneath the polymeric coating. This aluminosilicates is insoluble in the operational pH range (5–9), therefore aluminum (as Al 2 O 3 ) is undetectable at a sensitivity of 800 parts per 10 9 in the chromatographic effluent. The protective aluminosilicate can be removed by an acid wash. The physical/chemical changes in the column packing which result from caustic washing were studied by solid-state NMR and other physical techniques. The extent of modification, proposed protection mechanism and the influence on chromatographic performance are discussed." @default.
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- W2029541438 date "1990-01-01" @default.
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- W2029541438 title "Aluminum ion mediated stabilization of silica-based anion-exchange packings to caustic regenerants" @default.
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- W2029541438 doi "https://doi.org/10.1016/s0021-9673(01)81518-1" @default.
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