Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029542563> ?p ?o ?g. }
- W2029542563 endingPage "227" @default.
- W2029542563 startingPage "213" @default.
- W2029542563 abstract "The aim of the present study was to assess the effect of quercetin and imperatorin administered separately and in combination on apoptosis and autophagy induction in human cervical carcinoma HeLa cells and laryngeal carcinoma Hep-2 cells cultured in vitro. Conducted MTT measurements proved that quercetin and imperatorin displayed a strong antiproliferative activity manifested in markedly reduction of HeLa and Hep-2 cells viability as a result of treatment with 50 μM of each compound. Further cell staining assays revealed that concentration mentioned above generated the highest percentage of apoptotic cells especially in the case of application of both drugs for 48 h. Simultaneous quercetin and imperatorin administration induced apoptosis remarkably stronger than treatment with single drugs. Experiments at the molecular level confirmed these results accompanied with the decreased Hsp27 and Hsp72 expression and, in addition, with increased caspases activity. Autophagy was not observed and no significant changes in the expression of beclin-1 were noticed. Additionally, experiments were performed on the above-mentioned cell lines with blocked Hsp27 and Hsp72 expression. In these cells, no significant changes in the sensitivity to apoptosis induction upon quercetin and imperatorin treatment were observed. The present study has provided evidence supporting the potential of the combination of quercetin and imperatorin drugs as a novel tool to be used in anticancer therapy. Our results have also demonstrated that blocking of the Hsp27 and Hsp72 gene expression is not enough to sensitize cancer cells to programmed cell death induction in HeLa and Hep-2 cells." @default.
- W2029542563 created "2016-06-24" @default.
- W2029542563 creator A5040903348 @default.
- W2029542563 creator A5046573049 @default.
- W2029542563 creator A5065340140 @default.
- W2029542563 creator A5075887003 @default.
- W2029542563 creator A5086427423 @default.
- W2029542563 date "2014-03-30" @default.
- W2029542563 modified "2023-10-16" @default.
- W2029542563 title "Combined treatment with quercetin and imperatorin as a potent strategy for killing HeLa and Hep-2 cells" @default.
- W2029542563 cites W1539619858 @default.
- W2029542563 cites W1966176339 @default.
- W2029542563 cites W1976932448 @default.
- W2029542563 cites W1979851227 @default.
- W2029542563 cites W1991353142 @default.
- W2029542563 cites W1992401387 @default.
- W2029542563 cites W1995486038 @default.
- W2029542563 cites W2001591494 @default.
- W2029542563 cites W2002971852 @default.
- W2029542563 cites W2005202590 @default.
- W2029542563 cites W2008757142 @default.
- W2029542563 cites W2011893442 @default.
- W2029542563 cites W2012856926 @default.
- W2029542563 cites W2020158782 @default.
- W2029542563 cites W2026242631 @default.
- W2029542563 cites W2031366793 @default.
- W2029542563 cites W2031635845 @default.
- W2029542563 cites W2033134819 @default.
- W2029542563 cites W2039359375 @default.
- W2029542563 cites W2045271263 @default.
- W2029542563 cites W2046250764 @default.
- W2029542563 cites W2050289342 @default.
- W2029542563 cites W2051376250 @default.
- W2029542563 cites W2051479964 @default.
- W2029542563 cites W2062890522 @default.
- W2029542563 cites W2063839346 @default.
- W2029542563 cites W2063956958 @default.
- W2029542563 cites W2065878560 @default.
- W2029542563 cites W2072189442 @default.
- W2029542563 cites W2074169655 @default.
- W2029542563 cites W2082503341 @default.
- W2029542563 cites W2087906318 @default.
- W2029542563 cites W2093748380 @default.
- W2029542563 cites W2094992173 @default.
- W2029542563 cites W2100837269 @default.
- W2029542563 cites W2104381422 @default.
- W2029542563 cites W2105892303 @default.
- W2029542563 cites W2111797455 @default.
- W2029542563 cites W2117692326 @default.
- W2029542563 cites W2119800239 @default.
- W2029542563 cites W2125007784 @default.
- W2029542563 cites W2130704237 @default.
- W2029542563 cites W2135937574 @default.
- W2029542563 cites W2137819605 @default.
- W2029542563 cites W2138509357 @default.
- W2029542563 cites W2139196095 @default.
- W2029542563 cites W2142117669 @default.
- W2029542563 cites W2142802606 @default.
- W2029542563 cites W2145206598 @default.
- W2029542563 cites W2152792277 @default.
- W2029542563 cites W2153112470 @default.
- W2029542563 cites W2162363706 @default.
- W2029542563 cites W2163798716 @default.
- W2029542563 cites W2168313361 @default.
- W2029542563 cites W2616509991 @default.
- W2029542563 cites W4252238221 @default.
- W2029542563 cites W4293247451 @default.
- W2029542563 doi "https://doi.org/10.1007/s11010-014-2032-4" @default.
- W2029542563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4148393" @default.
- W2029542563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24682729" @default.
- W2029542563 hasPublicationYear "2014" @default.
- W2029542563 type Work @default.
- W2029542563 sameAs 2029542563 @default.
- W2029542563 citedByCount "40" @default.
- W2029542563 countsByYear W20295425632014 @default.
- W2029542563 countsByYear W20295425632015 @default.
- W2029542563 countsByYear W20295425632016 @default.
- W2029542563 countsByYear W20295425632017 @default.
- W2029542563 countsByYear W20295425632018 @default.
- W2029542563 countsByYear W20295425632019 @default.
- W2029542563 countsByYear W20295425632020 @default.
- W2029542563 countsByYear W20295425632021 @default.
- W2029542563 countsByYear W20295425632022 @default.
- W2029542563 countsByYear W20295425632023 @default.
- W2029542563 crossrefType "journal-article" @default.
- W2029542563 hasAuthorship W2029542563A5040903348 @default.
- W2029542563 hasAuthorship W2029542563A5046573049 @default.
- W2029542563 hasAuthorship W2029542563A5065340140 @default.
- W2029542563 hasAuthorship W2029542563A5075887003 @default.
- W2029542563 hasAuthorship W2029542563A5086427423 @default.
- W2029542563 hasBestOaLocation W20295425631 @default.
- W2029542563 hasConcept C104317684 @default.
- W2029542563 hasConcept C121608353 @default.
- W2029542563 hasConcept C153911025 @default.
- W2029542563 hasConcept C179998833 @default.
- W2029542563 hasConcept C185592680 @default.
- W2029542563 hasConcept C190283241 @default.
- W2029542563 hasConcept C202751555 @default.