FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029545735> ?p ?o ?g. }

• W2029545735 endingPage "1373" @default.
• W2029545735 startingPage "1364" @default.
• W2029545735 abstract "Background Exposure of the plasma protein factor XII (FXII) to an anionic surface generates activated FXII that not only triggers the intrinsic pathway of blood coagulation through the activation of FXI but also mediates various vascular responses through activation of the plasma contact system. While deficiencies of FXII are not associated with excessive bleeding, thrombosis models in factor-deficient animals have suggested that this protein contributes to stable thrombus formation. Therefore, FXII has emerged as an attractive therapeutic target to treat or prevent pathological thrombosis formation without increasing the risk for hemorrhage. Objectives Using an in vitro directed evolution and chemical biology approach, we sought to isolate a nuclease-resistant RNA aptamer that binds specifically to FXII and directly inhibits FXII coagulant function. Methods and Results We describe the isolation and characterization of a high-affinity RNA aptamer targeting FXII/activated FXII (FXIIa) that dose dependently prolongs fibrin clot formation and thrombin generation in clinical coagulation assays. This aptamer functions as a potent anticoagulant by inhibiting the autoactivation of FXII, as well as inhibiting intrinsic pathway activation (FXI activation). However, the aptamer does not affect the FXIIa-mediated activation of the proinflammatory kallikrein-kinin system (plasma kallikrein activation). Conclusions We have generated a specific and potent FXII/FXIIa aptamer anticoagulant that offers targeted inhibition of discrete macromolecular interactions involved in the activation of the intrinsic pathway of blood coagulation." @default.
• W2029545735 created "2016-06-24" @default.
• W2029545735 creator A5040370918 @default.
• W2029545735 creator A5040827962 @default.
• W2029545735 creator A5045554538 @default.
• W2029545735 creator A5075138833 @default.
• W2029545735 creator A5076079312 @default.
• W2029545735 creator A5082046353 @default.
• W2029545735 date "2013-07-01" @default.
• W2029545735 modified "2023-10-05" @default.
• W2029545735 title "Inhibiting the intrinsic pathway of coagulation with a factor XII–targeting RNA aptamer" @default.
• W2029545735 cites W1485228430 @default.
• W2029545735 cites W1600284253 @default.
• W2029545735 cites W1947012397 @default.
• W2029545735 cites W1966026137 @default.
• W2029545735 cites W1980585134 @default.
• W2029545735 cites W1983010160 @default.
• W2029545735 cites W1989364000 @default.
• W2029545735 cites W1995787074 @default.
• W2029545735 cites W2008819279 @default.
• W2029545735 cites W2019570438 @default.
• W2029545735 cites W2020115844 @default.
• W2029545735 cites W2021007949 @default.
• W2029545735 cites W2028757273 @default.
• W2029545735 cites W2036655503 @default.
• W2029545735 cites W2047144211 @default.
• W2029545735 cites W2053569777 @default.
• W2029545735 cites W2063706685 @default.
• W2029545735 cites W2067716683 @default.
• W2029545735 cites W2069100517 @default.
• W2029545735 cites W2077040278 @default.
• W2029545735 cites W2078094108 @default.
• W2029545735 cites W2078678101 @default.
• W2029545735 cites W2083884362 @default.
• W2029545735 cites W2107916818 @default.
• W2029545735 cites W2109078461 @default.
• W2029545735 cites W2109939055 @default.
• W2029545735 cites W2115570439 @default.
• W2029545735 cites W2119768870 @default.
• W2029545735 cites W2130153614 @default.
• W2029545735 cites W2137687839 @default.
• W2029545735 cites W2166268582 @default.
• W2029545735 cites W2226999514 @default.
• W2029545735 cites W2256946804 @default.
• W2029545735 doi "https://doi.org/10.1111/jth.12302" @default.
• W2029545735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3816843" @default.
• W2029545735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23692437" @default.
• W2029545735 hasPublicationYear "2013" @default.
• W2029545735 type Work @default.
• W2029545735 sameAs 2029545735 @default.
• W2029545735 citedByCount "85" @default.
• W2029545735 countsByYear W20295457352013 @default.
• W2029545735 countsByYear W20295457352014 @default.
• W2029545735 countsByYear W20295457352015 @default.
• W2029545735 countsByYear W20295457352016 @default.
• W2029545735 countsByYear W20295457352017 @default.
• W2029545735 countsByYear W20295457352018 @default.
• W2029545735 countsByYear W20295457352019 @default.
• W2029545735 countsByYear W20295457352020 @default.
• W2029545735 countsByYear W20295457352021 @default.
• W2029545735 countsByYear W20295457352022 @default.
• W2029545735 countsByYear W20295457352023 @default.
• W2029545735 crossrefType "journal-article" @default.
• W2029545735 hasAuthorship W2029545735A5040370918 @default.
• W2029545735 hasAuthorship W2029545735A5040827962 @default.
• W2029545735 hasAuthorship W2029545735A5045554538 @default.
• W2029545735 hasAuthorship W2029545735A5075138833 @default.
• W2029545735 hasAuthorship W2029545735A5076079312 @default.
• W2029545735 hasAuthorship W2029545735A5082046353 @default.
• W2029545735 hasBestOaLocation W20295457351 @default.
• W2029545735 hasConcept C126322002 @default.
• W2029545735 hasConcept C128972844 @default.
• W2029545735 hasConcept C152328610 @default.
• W2029545735 hasConcept C153911025 @default.
• W2029545735 hasConcept C181199279 @default.
• W2029545735 hasConcept C185592680 @default.
• W2029545735 hasConcept C203014093 @default.
• W2029545735 hasConcept C2777167447 @default.
• W2029545735 hasConcept C2777292125 @default.
• W2029545735 hasConcept C2777902427 @default.
• W2029545735 hasConcept C2778382381 @default.
• W2029545735 hasConcept C52853521 @default.
• W2029545735 hasConcept C54173615 @default.
• W2029545735 hasConcept C55493867 @default.
• W2029545735 hasConcept C71924100 @default.
• W2029545735 hasConcept C86803240 @default.
• W2029545735 hasConcept C89560881 @default.
• W2029545735 hasConcept C95444343 @default.
• W2029545735 hasConceptScore W2029545735C126322002 @default.
• W2029545735 hasConceptScore W2029545735C128972844 @default.
• W2029545735 hasConceptScore W2029545735C152328610 @default.
• W2029545735 hasConceptScore W2029545735C153911025 @default.
• W2029545735 hasConceptScore W2029545735C181199279 @default.
• W2029545735 hasConceptScore W2029545735C185592680 @default.
• W2029545735 hasConceptScore W2029545735C203014093 @default.
• W2029545735 hasConceptScore W2029545735C2777167447 @default.
• W2029545735 hasConceptScore W2029545735C2777292125 @default.
• W2029545735 hasConceptScore W2029545735C2777902427 @default.

• next