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- W2029546989 abstract "The experiments examine the effects of membrane potential on the time course of K+ contractures in small bundles of rat soleus and extensor digitorum longus (EDL) muscle fibers. Control K+ contractures were induced by exposure to a 200 mmol/L K+ solution in polarized fibers with a resting membrane potential of -83 mV (3.5 mmol/L K+), while test contractures were evoked with 200 mmol/L K+ from -46 mV, after 5, 10, and 30 min in a 30 mmol/L K+ conditioning solution. The decay times of the test K+ contracture in depolarized fibers were faster than those of the control K+ contracture in both soleus and EDL. A maximum reduction of 60% in the time for the contracture to decay from 90% to 10% was seen in soleus fibers after depolarizations lasting 10 min, while a reduction of 45% was seen in the decay time of EDL fibers after a 5-min depolarization. The amplitudes of the test contractures were 30% less than control after 5-min and 10-min depolarization and 50% less than control after 30 min. Analysis of the results suggests that the kinetics of excitation-contraction coupling may be altered in damaged muscle fibers." @default.
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- W2029546989 date "1996-08-01" @default.
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- W2029546989 title "Depolarization accelerates the decay of K+ contractures in rat skeletal muscle fibers" @default.
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- W2029546989 doi "https://doi.org/10.1002/(sici)1097-4598(199608)19:8<1025::aid-mus10>3.0.co;2-w" @default.
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