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• W2029549682 abstract "The bone marrow (BM) is an important compartment for T cell memory. In cytomegalovirus (CMV)-seropositive individuals peripheral blood (PB) CMV-specific T cells constitute a large fraction of PB T cells but are mostly differentiated effector/effector memory T cells with limited survival and proliferative potential. In this study, we performed a comprehensive analysis of the CMV-specific T cell response in BM studying both CD4+ and CD8+ T cell responses against overlapping peptide pools of the CMV proteins pp65 and immediate early protein-1. CMV-specific T cell responses were characterized ex vivo and after in vitro expansion of paired PB/BM samples by multiparameter flow cytometry determining surface phenotype, cytokine profile, and cytotoxic capability. Comparable frequencies of CMV-specific T cells were found in un-manipulated PB and BM. Both total CD4+ and CD8+ T cells could be more rapidly expanded from BM. Expanded BM T cells contained significantly higher frequencies of CMV-specific CD4+ T cells than PB. Furthermore, higher frequencies of specific CD4+ T cells from BM were multifunctional, characterized by simultaneous production of interferon-γ, tumor necrosis factor, and interleukin-2. Use of BM may thus facilitate more rapid generation of adoptive T cells with enhanced functionality." @default.
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• W2029549682 date "2009-11-01" @default.
• W2029549682 modified "2023-10-02" @default.
• W2029549682 title "Human Bone Marrow as a Source to Generate CMV-specific CD4+ T Cells With Multifunctional Capacity" @default.
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• W2029549682 doi "https://doi.org/10.1097/cji.0b013e3181b7be60" @default.
• W2029549682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19816191" @default.
• W2029549682 hasPublicationYear "2009" @default.
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