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- W2029551353 abstract "Cerebrospinal fluid (CSF) biomarkers detect early pathologic changes of Alzheimer's disease (AD). AD is associated with reduced default mode network (DMN) integrity as measured by resting state functional connectivity magnetic resonance imaging (rs-fcMRI). We assessed the relationship between rs-fcMRI measures of DMN integrity and CSF biomarker abnormalities in cognitively normal individuals. A total of 207 cognitively normal individuals, as assessed by the clinical dementia rating scale (CDR), underwent CSF assays of amyloid- Aβ 42 (Aβ 42), tau, and phosphorylated tau 181 (ptau 181) as well as rs-fcMRI (Table 1). The DMN was assessed by region-of-interest based and voxel-wise whole-brain analyses. Decreased CSF Aβ 42, increased CSF tau or CSF ptau 181 was independently associated with reduced DMN integrity, with the most prominent decreases in functional connectivity observed between the posterior cingulate and medial temporal regions. Observed reductions in functional connectivity were not attributable to age or structural atrophy in the posterior cingulate and medial temporal areas. A similar pattern of functional connectivity decrease was observed in both region-of-interest based and voxel-wise analyses for decreased CSF Aβ 42 or increased CSF ptau 181 (Figure 1). Voxel–wise analyses assessing functional connectivity of the posterior cingulate cortex (PCC) and medial temporal lobe (MTL) in cognitively normal individuals with abnormal levels of cerebrospinal fluid (CSF) Aβ42 or ptau181 A: PCC functional connectivity compared between CSF negative vs. CSF positive; B: PCC functional connectivity compared between CSF negative vs. CSF positive; C: MTL functional connectivity compared between CSF negative vs. CSF positive; D: MTL functional connectivity maps were compared using random effects analyses. Maps display random effects decreases in correlations (hot color) and each comparisons (cold color) in each comparisons. Maps were thresholded at a voxel-level [Z] > 2.5 and cluster size > 35 voxels, uncorrected for multiple comparisons." @default.
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- W2029551353 date "2013-07-01" @default.
- W2029551353 modified "2023-09-27" @default.
- W2029551353 title "P2-159: Cerebrospinal fluid beta-amyloid 42, tau, phosphorylated tau 181, and resting state functional connectivity" @default.
- W2029551353 doi "https://doi.org/10.1016/j.jalz.2013.05.804" @default.
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