FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029553312> ?p ?o ?g. }

• W2029553312 endingPage "564" @default.
• W2029553312 startingPage "557" @default.
• W2029553312 abstract "Previous data suggests that the adiposity signal leptin reduces food intake in part by enhancing sensitivity to short-term signals that promote meal termination, including glucagon-like peptide 1 (GLP-1). We hypothesized that maintenance on a high-fat (HF) diet, which causes resistance to leptin, would impair GLP-1's ability to reduce food intake. To test this hypothesis, we examined the anorexic responses to intraperitoneal injection of 100 μg/kg GLP-1 and 1 μg/kg exendin-4 (Ex-4), the potent, degradation resistant GLP-1 receptor agonist, in Wistar rats maintained on a low-fat (10%; LF) or HF (60%) diet for 4–6 weeks. Rats maintained on each of these diets were tested twice, once while consuming LF food and once while consuming HF food, to distinguish between effects of acute vs. chronic consumption of HF food. LF-maintained rats tested on LF diet reduced 60-min dark phase intake in response to GLP-1, but HF-maintained rats failed to respond to GLP-1 whether they were tested on HF or LF diet. LF-maintained rats tested on HF diet also showed no response, suggesting that even brief exposure to HF diet can impair sensitivity to GLP-1 receptor activation. Both LF- and HF-maintained rats showed significant anorexic responses to Ex4 at 4 h post-treatment, but only LF-maintained rats had significantly reduced intake and body weight 24 h after injections. To determine whether the ability of endogenous GLP-1 to promote satiation is impaired by HF maintenance, we examined the response to exendin 3 (9–39) (Ex9), a GLP-1 receptor antagonist. In LF-maintained rats, Ex9 increased intake significantly, but HF-maintained rats reduced food intake in response to Ex9. These data support the suggestion that maintenance on HF diet reduces the anorexic effects of GLP-1 receptor activation, and this phenomenon may contribute to overconsumption of high-fat foods." @default.
• W2029553312 created "2016-06-24" @default.
• W2029553312 creator A5010570874 @default.
• W2029553312 creator A5014744090 @default.
• W2029553312 creator A5043008741 @default.
• W2029553312 creator A5047096158 @default.
• W2029553312 creator A5053625751 @default.
• W2029553312 creator A5058291614 @default.
• W2029553312 creator A5058535825 @default.
• W2029553312 date "2011-07-01" @default.
• W2029553312 modified "2023-10-18" @default.
• W2029553312 title "Maintenance on a high-fat diet impairs the anorexic response to glucagon-like-peptide-1 receptor activation" @default.
• W2029553312 cites W1975732497 @default.
• W2029553312 cites W1978297557 @default.
• W2029553312 cites W1983901940 @default.
• W2029553312 cites W1995252549 @default.
• W2029553312 cites W1999938411 @default.
• W2029553312 cites W2003270207 @default.
• W2029553312 cites W2011847859 @default.
• W2029553312 cites W2013665956 @default.
• W2029553312 cites W2030157762 @default.
• W2029553312 cites W2057410639 @default.
• W2029553312 cites W2058747032 @default.
• W2029553312 cites W2064445900 @default.
• W2029553312 cites W2065919617 @default.
• W2029553312 cites W2074779331 @default.
• W2029553312 cites W2077548379 @default.
• W2029553312 cites W2082052031 @default.
• W2029553312 cites W2089158202 @default.
• W2029553312 cites W2096780893 @default.
• W2029553312 cites W2106270379 @default.
• W2029553312 cites W2107838780 @default.
• W2029553312 cites W2114711378 @default.
• W2029553312 cites W2137060566 @default.
• W2029553312 cites W2141432557 @default.
• W2029553312 cites W2150766673 @default.
• W2029553312 cites W2159205789 @default.
• W2029553312 cites W2161407981 @default.
• W2029553312 cites W2162826365 @default.
• W2029553312 cites W2167984392 @default.
• W2029553312 doi "https://doi.org/10.1016/j.physbeh.2011.04.005" @default.
• W2029553312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3666166" @default.
• W2029553312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21515295" @default.
• W2029553312 hasPublicationYear "2011" @default.
• W2029553312 type Work @default.
• W2029553312 sameAs 2029553312 @default.
• W2029553312 citedByCount "65" @default.
• W2029553312 countsByYear W20295533122012 @default.
• W2029553312 countsByYear W20295533122013 @default.
• W2029553312 countsByYear W20295533122014 @default.
• W2029553312 countsByYear W20295533122015 @default.
• W2029553312 countsByYear W20295533122016 @default.
• W2029553312 countsByYear W20295533122017 @default.
• W2029553312 countsByYear W20295533122018 @default.
• W2029553312 countsByYear W20295533122019 @default.
• W2029553312 countsByYear W20295533122020 @default.
• W2029553312 countsByYear W20295533122021 @default.
• W2029553312 countsByYear W20295533122022 @default.
• W2029553312 countsByYear W20295533122023 @default.
• W2029553312 crossrefType "journal-article" @default.
• W2029553312 hasAuthorship W2029553312A5010570874 @default.
• W2029553312 hasAuthorship W2029553312A5014744090 @default.
• W2029553312 hasAuthorship W2029553312A5043008741 @default.
• W2029553312 hasAuthorship W2029553312A5047096158 @default.
• W2029553312 hasAuthorship W2029553312A5053625751 @default.
• W2029553312 hasAuthorship W2029553312A5058291614 @default.
• W2029553312 hasAuthorship W2029553312A5058535825 @default.
• W2029553312 hasBestOaLocation W20295533122 @default.
• W2029553312 hasConcept C126322002 @default.
• W2029553312 hasConcept C134018914 @default.
• W2029553312 hasConcept C14372207 @default.
• W2029553312 hasConcept C170493617 @default.
• W2029553312 hasConcept C185280430 @default.
• W2029553312 hasConcept C2776398474 @default.
• W2029553312 hasConcept C2777180221 @default.
• W2029553312 hasConcept C2778345441 @default.
• W2029553312 hasConcept C2778938600 @default.
• W2029553312 hasConcept C2780613262 @default.
• W2029553312 hasConcept C3018685816 @default.
• W2029553312 hasConcept C511355011 @default.
• W2029553312 hasConcept C555293320 @default.
• W2029553312 hasConcept C71924100 @default.
• W2029553312 hasConceptScore W2029553312C126322002 @default.
• W2029553312 hasConceptScore W2029553312C134018914 @default.
• W2029553312 hasConceptScore W2029553312C14372207 @default.
• W2029553312 hasConceptScore W2029553312C170493617 @default.
• W2029553312 hasConceptScore W2029553312C185280430 @default.
• W2029553312 hasConceptScore W2029553312C2776398474 @default.
• W2029553312 hasConceptScore W2029553312C2777180221 @default.
• W2029553312 hasConceptScore W2029553312C2778345441 @default.
• W2029553312 hasConceptScore W2029553312C2778938600 @default.
• W2029553312 hasConceptScore W2029553312C2780613262 @default.
• W2029553312 hasConceptScore W2029553312C3018685816 @default.
• W2029553312 hasConceptScore W2029553312C511355011 @default.
• W2029553312 hasConceptScore W2029553312C555293320 @default.
• W2029553312 hasConceptScore W2029553312C71924100 @default.
• W2029553312 hasIssue "5" @default.
• W2029553312 hasLocation W20295533121 @default.

• next