Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029553495> ?p ?o ?g. }
- W2029553495 endingPage "50" @default.
- W2029553495 startingPage "45" @default.
- W2029553495 abstract "Choline phosphoglycerides comprise almost half of vertebrate retinal phospholipids. This lipid pool contains the precursor of the potent lipid mediator, platelet-activating factor. The acyl composition and distribution of the different subclasses of the choline phosphoglycerides (alkylacyl- [or the precursor of platelet-activating factor], alkenylacyl- [or choline plasmalogen] and diacyl-glycero-3-phosphocholine) were studied in intact rabbit retina, neural retina and rod outer segments. Choline phosphoglycerides were isolated by high performance liquid chromatography and derivatized by acetylation after phospholipase C treatment. The derivatives were purified by high performance liquid chromatography and subjected to methanolysis. Fatty acids were analyzed by capillary gas liquid chromatography. In the intact retina and in the neural retina, the alkylacyl-glycero-3-phosphocholine and alkenylacyl-glycero-3-phosphocholine comprise 1.2% and 1.5%, respectively, of the total choline phosphoglycerides, whereas the rod outer segments contain twice the proportion of the precursor of platelet-activating factor and no detectable plasmalogens. On a mole percent basis, arachidonic acid was highest in the neural retinal alkenylacyl-glycero-3-phos-phocholine (27%), 18% in the alkylacyl-glycero-3-phospho-choline and only 5% in the diacyl-glycero-3-phosphocholine. However, alkylacyl-glycero-3-phosphocholine from rod outer segments was enriched in docosapentaenoic acid (18%) while arachidonic acid was in the 3–4% range. Our results suggest that, in the neural retina, alkyl-arachidonoyl-glycero-3-phospho-choline is a source of both platelet-activating factor and of arachidonic acid which may be a substrate for both prostaglandins and lipoxygenase metabolites during an inflammatory episode and may contribute to the retinal pathology." @default.
- W2029553495 created "2016-06-24" @default.
- W2029553495 creator A5015926296 @default.
- W2029553495 creator A5068398524 @default.
- W2029553495 creator A5072450773 @default.
- W2029553495 date "1994-01-01" @default.
- W2029553495 modified "2023-10-14" @default.
- W2029553495 title "Differences in the acyl composition of the platelet-activating factor (PAF) precursor and other choline phosphoglycerides of the rabbit retinal rod outer segments and neural retina" @default.
- W2029553495 cites W1480219069 @default.
- W2029553495 cites W1512762418 @default.
- W2029553495 cites W1530987995 @default.
- W2029553495 cites W1543719240 @default.
- W2029553495 cites W1562330161 @default.
- W2029553495 cites W1563717384 @default.
- W2029553495 cites W1578895875 @default.
- W2029553495 cites W1983685995 @default.
- W2029553495 cites W1984855675 @default.
- W2029553495 cites W1995125575 @default.
- W2029553495 cites W1999105737 @default.
- W2029553495 cites W1999314611 @default.
- W2029553495 cites W2002596361 @default.
- W2029553495 cites W2003709444 @default.
- W2029553495 cites W2013238661 @default.
- W2029553495 cites W2017617178 @default.
- W2029553495 cites W2019927981 @default.
- W2029553495 cites W2026141491 @default.
- W2029553495 cites W2029132406 @default.
- W2029553495 cites W2034700091 @default.
- W2029553495 cites W2035596501 @default.
- W2029553495 cites W2043535900 @default.
- W2029553495 cites W2044337730 @default.
- W2029553495 cites W2044895405 @default.
- W2029553495 cites W2068746547 @default.
- W2029553495 cites W2069587062 @default.
- W2029553495 cites W2079332429 @default.
- W2029553495 cites W2096165281 @default.
- W2029553495 cites W2136346557 @default.
- W2029553495 cites W2413286215 @default.
- W2029553495 cites W302906649 @default.
- W2029553495 cites W4234055679 @default.
- W2029553495 cites W64761778 @default.
- W2029553495 cites W93225780 @default.
- W2029553495 doi "https://doi.org/10.3109/02713689409042397" @default.
- W2029553495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8156825" @default.
- W2029553495 hasPublicationYear "1994" @default.
- W2029553495 type Work @default.
- W2029553495 sameAs 2029553495 @default.
- W2029553495 citedByCount "7" @default.
- W2029553495 countsByYear W20295534952021 @default.
- W2029553495 countsByYear W20295534952022 @default.
- W2029553495 crossrefType "journal-article" @default.
- W2029553495 hasAuthorship W2029553495A5015926296 @default.
- W2029553495 hasAuthorship W2029553495A5068398524 @default.
- W2029553495 hasAuthorship W2029553495A5072450773 @default.
- W2029553495 hasConcept C134018914 @default.
- W2029553495 hasConcept C169760540 @default.
- W2029553495 hasConcept C181199279 @default.
- W2029553495 hasConcept C185592680 @default.
- W2029553495 hasConcept C2776330855 @default.
- W2029553495 hasConcept C2776923060 @default.
- W2029553495 hasConcept C2777093970 @default.
- W2029553495 hasConcept C2778078955 @default.
- W2029553495 hasConcept C2778918659 @default.
- W2029553495 hasConcept C2779020240 @default.
- W2029553495 hasConcept C2780827179 @default.
- W2029553495 hasConcept C2781123555 @default.
- W2029553495 hasConcept C41625074 @default.
- W2029553495 hasConcept C43617362 @default.
- W2029553495 hasConcept C55493867 @default.
- W2029553495 hasConcept C86803240 @default.
- W2029553495 hasConceptScore W2029553495C134018914 @default.
- W2029553495 hasConceptScore W2029553495C169760540 @default.
- W2029553495 hasConceptScore W2029553495C181199279 @default.
- W2029553495 hasConceptScore W2029553495C185592680 @default.
- W2029553495 hasConceptScore W2029553495C2776330855 @default.
- W2029553495 hasConceptScore W2029553495C2776923060 @default.
- W2029553495 hasConceptScore W2029553495C2777093970 @default.
- W2029553495 hasConceptScore W2029553495C2778078955 @default.
- W2029553495 hasConceptScore W2029553495C2778918659 @default.
- W2029553495 hasConceptScore W2029553495C2779020240 @default.
- W2029553495 hasConceptScore W2029553495C2780827179 @default.
- W2029553495 hasConceptScore W2029553495C2781123555 @default.
- W2029553495 hasConceptScore W2029553495C41625074 @default.
- W2029553495 hasConceptScore W2029553495C43617362 @default.
- W2029553495 hasConceptScore W2029553495C55493867 @default.
- W2029553495 hasConceptScore W2029553495C86803240 @default.
- W2029553495 hasIssue "1" @default.
- W2029553495 hasLocation W20295534951 @default.
- W2029553495 hasLocation W20295534952 @default.
- W2029553495 hasOpenAccess W2029553495 @default.
- W2029553495 hasPrimaryLocation W20295534951 @default.
- W2029553495 hasRelatedWork W1995477876 @default.
- W2029553495 hasRelatedWork W2018486597 @default.
- W2029553495 hasRelatedWork W2080895606 @default.
- W2029553495 hasRelatedWork W2088428258 @default.
- W2029553495 hasRelatedWork W2139806709 @default.
- W2029553495 hasRelatedWork W2149872260 @default.
- W2029553495 hasRelatedWork W2154129829 @default.