Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029553530> ?p ?o ?g. }
- W2029553530 endingPage "36" @default.
- W2029553530 startingPage "26" @default.
- W2029553530 abstract "Alzheimer disease (AD) is associated with the accumulation in the brain of extracellular neuritic plaques composed mainly of β-amyloid (Aβ) and of intracellular neurofibrillary tangles composed of hyperphosphorylated forms of the microtubule-associated protein tau. It is also associated with other features that have received less attention, including aberrant phospholipid, cholesterol, and calcium metabolism, and altered mitochondrial function and dynamics. The underlying mechanism(s) that might explain these observations are currently unknown. We recently showed that presenilin-1 (PS1), presenilin-2 (PS2), and γ-secretase activity, which processes the amyloid precursor protein (APP) to generate Aβ, are located predominantly in a specialized subcompartment of the endoplasmic reticulum (ER) that is physically and biochemically connected to mitochondria, called mitochondria-associated ER membranes (MAM). MAM is an intracellular lipid raft-like structure intimately involved in cholesterol and phospholipid lipid metabolism, in calcium homeostasis, and in mitochondrial function and dynamics. The coincidence of the functions associated with MAM with the symptomatology of AD led us to speculate that presenilins play a role in maintaining MAM function. We found that, consistent with this supposition, both MAM function and ER–mitochondrial connectivity are increased significantly in AD, which may help explain many of the biochemical and morphological features of the disease. Based on these findings, we propose that AD is fundamentally a disorder of ER–mitochondrial communication (the “MAM hypothesis”). This article is part of a Special Issue entitled ‘Mitochondrial function and dysfunction in neurodegeneration’." @default.
- W2029553530 created "2016-06-24" @default.
- W2029553530 creator A5071211755 @default.
- W2029553530 creator A5083891032 @default.
- W2029553530 date "2013-07-01" @default.
- W2029553530 modified "2023-09-27" @default.
- W2029553530 title "Mitochondria-associated ER membranes in Alzheimer disease" @default.
- W2029553530 cites W1490169551 @default.
- W2029553530 cites W1502115006 @default.
- W2029553530 cites W1506557404 @default.
- W2029553530 cites W1526991210 @default.
- W2029553530 cites W1581881472 @default.
- W2029553530 cites W1587655337 @default.
- W2029553530 cites W1597345104 @default.
- W2029553530 cites W1605199145 @default.
- W2029553530 cites W1669771493 @default.
- W2029553530 cites W1892274889 @default.
- W2029553530 cites W1928655587 @default.
- W2029553530 cites W193084426 @default.
- W2029553530 cites W1965728426 @default.
- W2029553530 cites W1965893615 @default.
- W2029553530 cites W1968257316 @default.
- W2029553530 cites W1974768040 @default.
- W2029553530 cites W1975218786 @default.
- W2029553530 cites W1975600949 @default.
- W2029553530 cites W1977172528 @default.
- W2029553530 cites W1977956545 @default.
- W2029553530 cites W1979158332 @default.
- W2029553530 cites W1980883732 @default.
- W2029553530 cites W1981039973 @default.
- W2029553530 cites W1981049765 @default.
- W2029553530 cites W1981287298 @default.
- W2029553530 cites W1985538633 @default.
- W2029553530 cites W1986101977 @default.
- W2029553530 cites W1987088763 @default.
- W2029553530 cites W1988525955 @default.
- W2029553530 cites W1990782273 @default.
- W2029553530 cites W1991518782 @default.
- W2029553530 cites W1993231091 @default.
- W2029553530 cites W1993630867 @default.
- W2029553530 cites W1995954863 @default.
- W2029553530 cites W1997366047 @default.
- W2029553530 cites W1998026822 @default.
- W2029553530 cites W1998332163 @default.
- W2029553530 cites W1998385675 @default.
- W2029553530 cites W1998510870 @default.
- W2029553530 cites W1998858575 @default.
- W2029553530 cites W2000075190 @default.
- W2029553530 cites W2000621526 @default.
- W2029553530 cites W2001828696 @default.
- W2029553530 cites W2002057703 @default.
- W2029553530 cites W2003890494 @default.
- W2029553530 cites W2005017513 @default.
- W2029553530 cites W2005070116 @default.
- W2029553530 cites W2005216847 @default.
- W2029553530 cites W2006035554 @default.
- W2029553530 cites W2009594625 @default.
- W2029553530 cites W2010710842 @default.
- W2029553530 cites W2013312860 @default.
- W2029553530 cites W2015536770 @default.
- W2029553530 cites W2015727986 @default.
- W2029553530 cites W2015902113 @default.
- W2029553530 cites W2019079031 @default.
- W2029553530 cites W2024941524 @default.
- W2029553530 cites W2028533061 @default.
- W2029553530 cites W2028974698 @default.
- W2029553530 cites W2029222224 @default.
- W2029553530 cites W2029279326 @default.
- W2029553530 cites W2030650261 @default.
- W2029553530 cites W2036557271 @default.
- W2029553530 cites W2039010788 @default.
- W2029553530 cites W2039069312 @default.
- W2029553530 cites W2039255874 @default.
- W2029553530 cites W2040901772 @default.
- W2029553530 cites W2040927130 @default.
- W2029553530 cites W2045106215 @default.
- W2029553530 cites W2045766246 @default.
- W2029553530 cites W2046475919 @default.
- W2029553530 cites W2048330056 @default.
- W2029553530 cites W2050586736 @default.
- W2029553530 cites W2053756526 @default.
- W2029553530 cites W2054473727 @default.
- W2029553530 cites W2054600904 @default.
- W2029553530 cites W2055776806 @default.
- W2029553530 cites W2057420163 @default.
- W2029553530 cites W2057455189 @default.
- W2029553530 cites W2059945718 @default.
- W2029553530 cites W2066842810 @default.
- W2029553530 cites W2067772115 @default.
- W2029553530 cites W2070022566 @default.
- W2029553530 cites W2070447989 @default.
- W2029553530 cites W2070752626 @default.
- W2029553530 cites W2072329091 @default.
- W2029553530 cites W2072881240 @default.
- W2029553530 cites W2073028992 @default.
- W2029553530 cites W2080057730 @default.
- W2029553530 cites W2081458774 @default.
- W2029553530 cites W2081467822 @default.