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- W2029553636 abstract "We studied the binding of [125I]Tyr11-somatostatin-14 and [125I]Leu8,d-Trp22, Tyr25-somatostatin-28 to frozen, unfixed sections of C57BL/6J mouse eyes with autoradiography. Specific binding of both ligands occurred in 3 maxima, a broad band extending from the retinal ganglion cell to the inner nuclear layers, a narrow and inconstant band over the outer plexiform layer, and a band over the retinal pigment epithelium and choroid. We quantified the label over the inner plexiform layer and found evidence for a single, saturable binding site after Scatchard analysis of saturation binding data. With [125I]Tyr11-somatostatin-14 the dissociation constant (Kd) was 1.48 nM and the total number of binding sites (Bmax) was 68 fmol/mg protein; in competition experiments the inhibitory binding constant (Ki) was 900 pM for somatostatin-14 and 350 pM for somatostatin-28. With [125I]Leu8,d-Trp22, Tyr25-somatostatin-28, Kd was 625 pM and Bmax was 69 fmol/mg protein: in competition experiments Ki was 4.58 nM for somatostatin-14 and 710 pM for somatostatin-28. These results demonstrate the existence of somatostatin receptors in the inner plexiform layer of the retina that appear to have greater specificity for somatostatin-28 than for somatostatin-14." @default.
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- W2029553636 date "1989-01-01" @default.
- W2029553636 modified "2023-09-23" @default.
- W2029553636 title "Localization and characterization of somatostatin binding sites in the mouse retina" @default.
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- W2029553636 doi "https://doi.org/10.1016/0006-8993(89)91538-2" @default.
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