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- W2029554998 abstract "By combining biochemical and nanoindentation techniques we compare A, B and C nuclear capsids of the Herpes Simplex Virus type 1. Atomic Force Microscopy (AFM) experiments show that A and C capsids are mechanically indistinguishable whereas B capsids already break at much lower forces. By extracting the pentamers with 2.0 M GuHCl or 6.0 M Urea we show the anticipated increased flexibility of all three capsid types. Whereas the breaking force of the extracted B capsids does not greatly change, the extracted A and C capsids show a drop in their breaking force to approximately the value of the B capsids. The presented data is a strong indication that upon DNA packaging a conformational change of and/or protein addition to the capsid occurs. This process leads to a mechanical reinforcement of the particles at or near the pentamers. The data furthermore supports the view that A capsids are particles that started DNA packaging, but were not able to complete it. The figure shows an AFM image of a HSV capsid with as inset a schematic depicting the hexamers and pentamers (inset from Zhou et al. Science, 288, 877)View Large Image | View Hi-Res Image | Download PowerPoint Slide" @default.
- W2029554998 created "2016-06-24" @default.
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- W2029554998 date "2009-02-01" @default.
- W2029554998 modified "2023-09-27" @default.
- W2029554998 title "Capsid Reinforcement of Herpes Simplex Virus Triggered by DNA Packaging" @default.
- W2029554998 doi "https://doi.org/10.1016/j.bpj.2008.12.2165" @default.
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