FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029557517> ?p ?o ?g. }

• W2029557517 endingPage "F1231" @default.
• W2029557517 startingPage "F1226" @default.
• W2029557517 abstract "Aldosterone enhances Na + reabsorption via epithelial Na + channels (ENaC). Aldosterone also stimulates the protein kinase ERK1/2- and the epidermal growth factor (EGF) receptor (EGFR)-signaling pathway. Yet EGF and ERK1/2 are known inhibitors of ENaC-mediated Na + reabsorption. In the present study, using the well-established Madin-Darby canine kidney C7 cell line, we tested the hypothesis that EGFR represents a negative-feedback control for chronic aldosterone-induced Na + reabsorption [amiloride-inhibitable short-circuit current ( I sc )]. Mineralocorticoid receptor expression was confirmed by RT-PCR and Western blot analysis. Aldosterone enhanced ERK1/2 phosphorylation in an EGFR-dependent way. Furthermore, aldosterone stimulated EGFR expression. Aldosterone (10 nmol/l) induced a small transient increase in I sc under control conditions. Inhibition of ERK1/2 phosphorylation with U-0126 (10 μmol/l) stimulated I sc , indicating constitutive ENaC inhibition. Aldosterone exerted a significantly larger effect in the presence of U-0126 than without U-0126. EGF (10 μg/l) inhibited I sc , whereas inhibition of EGFR kinase by tyrphostin AG-1478 (100 nmol/l) enhanced I sc . Aldosterone was more effective in the presence of AG-1478 than without AG-1478. In summary, we propose that the EGFR-signaling cascade can serve as a negative-feedback control to limit the effect of aldosterone-induced Na + reabsorption." @default.
• W2029557517 created "2016-06-24" @default.
• W2029557517 creator A5011979956 @default.
• W2029557517 creator A5035335028 @default.
• W2029557517 creator A5035356482 @default.
• W2029557517 creator A5077456937 @default.
• W2029557517 creator A5090985052 @default.
• W2029557517 date "2004-06-01" @default.
• W2029557517 modified "2023-09-26" @default.
• W2029557517 title "Evidence for epidermal growth factor receptor as negative-feedback control in aldosterone-induced Na⁺ reabsorption" @default.
• W2029557517 cites W1972577144 @default.
• W2029557517 cites W1973794764 @default.
• W2029557517 cites W1981924141 @default.
• W2029557517 cites W1983297072 @default.
• W2029557517 cites W1986506791 @default.
• W2029557517 cites W1988201508 @default.
• W2029557517 cites W1992494265 @default.
• W2029557517 cites W1999585924 @default.
• W2029557517 cites W1999805805 @default.
• W2029557517 cites W2004403689 @default.
• W2029557517 cites W2006079083 @default.
• W2029557517 cites W2012165429 @default.
• W2029557517 cites W2013673967 @default.
• W2029557517 cites W2015497140 @default.
• W2029557517 cites W2031928941 @default.
• W2029557517 cites W2035708557 @default.
• W2029557517 cites W2045593302 @default.
• W2029557517 cites W2063231321 @default.
• W2029557517 cites W2066498455 @default.
• W2029557517 cites W2071457582 @default.
• W2029557517 cites W2073862596 @default.
• W2029557517 cites W2076928432 @default.
• W2029557517 cites W2078826554 @default.
• W2029557517 cites W2080414061 @default.
• W2029557517 cites W2096737170 @default.
• W2029557517 cites W2122603754 @default.
• W2029557517 cites W2130392031 @default.
• W2029557517 cites W2136519986 @default.
• W2029557517 cites W2137628287 @default.
• W2029557517 cites W2144868296 @default.
• W2029557517 cites W2186559780 @default.
• W2029557517 cites W2187055353 @default.
• W2029557517 cites W2332019175 @default.
• W2029557517 cites W2441995366 @default.
• W2029557517 cites W2474058305 @default.
• W2029557517 cites W4240682011 @default.
• W2029557517 doi "https://doi.org/10.1152/ajprenal.00378.2003" @default.
• W2029557517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14749256" @default.
• W2029557517 hasPublicationYear "2004" @default.
• W2029557517 type Work @default.
• W2029557517 sameAs 2029557517 @default.
• W2029557517 citedByCount "53" @default.
• W2029557517 countsByYear W20295575172012 @default.
• W2029557517 countsByYear W20295575172013 @default.
• W2029557517 countsByYear W20295575172014 @default.
• W2029557517 countsByYear W20295575172015 @default.
• W2029557517 countsByYear W20295575172016 @default.
• W2029557517 countsByYear W20295575172017 @default.
• W2029557517 countsByYear W20295575172018 @default.
• W2029557517 countsByYear W20295575172019 @default.
• W2029557517 countsByYear W20295575172020 @default.
• W2029557517 countsByYear W20295575172021 @default.
• W2029557517 countsByYear W20295575172023 @default.
• W2029557517 crossrefType "journal-article" @default.
• W2029557517 hasAuthorship W2029557517A5011979956 @default.
• W2029557517 hasAuthorship W2029557517A5035335028 @default.
• W2029557517 hasAuthorship W2029557517A5035356482 @default.
• W2029557517 hasAuthorship W2029557517A5077456937 @default.
• W2029557517 hasAuthorship W2029557517A5090985052 @default.
• W2029557517 hasConcept C11960822 @default.
• W2029557517 hasConcept C126322002 @default.
• W2029557517 hasConcept C134018914 @default.
• W2029557517 hasConcept C170493617 @default.
• W2029557517 hasConcept C178790620 @default.
• W2029557517 hasConcept C185592680 @default.
• W2029557517 hasConcept C189135053 @default.
• W2029557517 hasConcept C2776362946 @default.
• W2029557517 hasConcept C2778525890 @default.
• W2029557517 hasConcept C2779438470 @default.
• W2029557517 hasConcept C2780091579 @default.
• W2029557517 hasConcept C537181965 @default.
• W2029557517 hasConcept C56906281 @default.
• W2029557517 hasConcept C57476199 @default.
• W2029557517 hasConcept C6507245 @default.
• W2029557517 hasConcept C71924100 @default.
• W2029557517 hasConcept C86803240 @default.
• W2029557517 hasConcept C95444343 @default.
• W2029557517 hasConceptScore W2029557517C11960822 @default.
• W2029557517 hasConceptScore W2029557517C126322002 @default.
• W2029557517 hasConceptScore W2029557517C134018914 @default.
• W2029557517 hasConceptScore W2029557517C170493617 @default.
• W2029557517 hasConceptScore W2029557517C178790620 @default.
• W2029557517 hasConceptScore W2029557517C185592680 @default.
• W2029557517 hasConceptScore W2029557517C189135053 @default.
• W2029557517 hasConceptScore W2029557517C2776362946 @default.
• W2029557517 hasConceptScore W2029557517C2778525890 @default.
• W2029557517 hasConceptScore W2029557517C2779438470 @default.
• W2029557517 hasConceptScore W2029557517C2780091579 @default.

• next