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- W2029557691 abstract "In general, oxidative stress is defined as the imbalance between the production of reactive oxygen species (ROS) and reactive nitrogenspecies (RNS) andantioxidantdefensemechanisms. These toxic molecules become highly reactive in their formation because of their altered number of unpaired valence electrons. It corresponds to the mitochondria to be the main producer of ROS, generating the bulk of the respiratory chain complexes I and III, following the flow of electrons between the two complexes. However, the production of ROS under physiological conditions becomes essential for maintaining life and a baseline level of ROS are involved in numerous mechanisms such as bactericidal activity of phagocytes or signal transduction, regulation of cell growth or the redox state of cells, including others.1 High levels of oxidative stress have been implicated as the primary and/or secondary event in numerous diseases such as rheumatoid arthritis, Parkinson’s, Alzheimer’s, atherosclerosis, cardiovascular diseases and diabetes mellitus.2" @default.
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- W2029557691 date "2011-09-01" @default.
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- W2029557691 title "Oxidative Stress in Fibromyalgia: Pathophysiology and Clinical Implications" @default.
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