FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029560072> ?p ?o ?g. }

• W2029560072 endingPage "335" @default.
• W2029560072 startingPage "328" @default.
• W2029560072 abstract "This study was conducted to examine the bone and body composition effects of S-4, an aryl-propionamide derived Selective Androgen Receptor Modulator (SARM) in an ovariectomy induced model of accelerated bone loss. One hundred twenty female Sprague–Dawley rats aged to twenty-three weeks were randomly assigned to twelve treatment groups. Drug treatment was initiated immediately following ovariectomy and continued for one hundred twenty days. Whole body bone mineral density (BMD), body composition, and lumbar vertebrae BMD were measured by dual energy x-ray absorptiometry. More stringent regional pQCT and biomechanical strength testing was performed on excised femurs. We found that S-4 treatment maintained whole body and trabecular BMD, cortical content, and increased bone strength while decreasing body fat in these animals. The data presented herein show the protective skeletal effects of S-4. Our previous reports have shown the tissue selectivity and muscle anabolic activity of S-4. Together these data suggest that S-4 could reduce the incidence of fracture via two different mechanisms (i.e., via direct effects in bone and reducing the incidence of falls through increased muscle strength). This approach to fracture reduction would be advantageous over current therapies in these patients which are primarily antiresorptive in nature." @default.
• W2029560072 created "2016-06-24" @default.
• W2029560072 creator A5002243266 @default.
• W2029560072 creator A5016676195 @default.
• W2029560072 creator A5019289252 @default.
• W2029560072 creator A5036514687 @default.
• W2029560072 creator A5050406332 @default.
• W2029560072 creator A5067659573 @default.
• W2029560072 creator A5082299340 @default.
• W2029560072 date "2006-10-25" @default.
• W2029560072 modified "2023-10-18" @default.
• W2029560072 title "Selective Androgen Receptor Modulator (SARM) Treatment Prevents Bone Loss and Reduces Body Fat in Ovariectomized Rats" @default.
• W2029560072 cites W1897403216 @default.
• W2029560072 cites W1964444007 @default.
• W2029560072 cites W1965600017 @default.
• W2029560072 cites W1976003215 @default.
• W2029560072 cites W1980596434 @default.
• W2029560072 cites W1994175059 @default.
• W2029560072 cites W1998111806 @default.
• W2029560072 cites W2014640240 @default.
• W2029560072 cites W2018317782 @default.
• W2029560072 cites W2038310509 @default.
• W2029560072 cites W2039342183 @default.
• W2029560072 cites W2039696804 @default.
• W2029560072 cites W2044703239 @default.
• W2029560072 cites W2047794574 @default.
• W2029560072 cites W2053309525 @default.
• W2029560072 cites W2053820214 @default.
• W2029560072 cites W2059874795 @default.
• W2029560072 cites W2065224313 @default.
• W2029560072 cites W2076367375 @default.
• W2029560072 cites W2081873302 @default.
• W2029560072 cites W2086671416 @default.
• W2029560072 cites W2089069885 @default.
• W2029560072 cites W2107497394 @default.
• W2029560072 cites W2124052755 @default.
• W2029560072 cites W2125481696 @default.
• W2029560072 cites W2127016457 @default.
• W2029560072 cites W2128997526 @default.
• W2029560072 cites W2144000500 @default.
• W2029560072 cites W2275993104 @default.
• W2029560072 cites W4229861721 @default.
• W2029560072 cites W4241684304 @default.
• W2029560072 doi "https://doi.org/10.1007/s11095-006-9152-9" @default.
• W2029560072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2039878" @default.
• W2029560072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17063395" @default.
• W2029560072 hasPublicationYear "2006" @default.
• W2029560072 type Work @default.
• W2029560072 sameAs 2029560072 @default.
• W2029560072 citedByCount "94" @default.
• W2029560072 countsByYear W20295600722012 @default.
• W2029560072 countsByYear W20295600722013 @default.
• W2029560072 countsByYear W20295600722014 @default.
• W2029560072 countsByYear W20295600722015 @default.
• W2029560072 countsByYear W20295600722016 @default.
• W2029560072 countsByYear W20295600722017 @default.
• W2029560072 countsByYear W20295600722018 @default.
• W2029560072 countsByYear W20295600722019 @default.
• W2029560072 countsByYear W20295600722020 @default.
• W2029560072 countsByYear W20295600722021 @default.
• W2029560072 countsByYear W20295600722022 @default.
• W2029560072 countsByYear W20295600722023 @default.
• W2029560072 crossrefType "journal-article" @default.
• W2029560072 hasAuthorship W2029560072A5002243266 @default.
• W2029560072 hasAuthorship W2029560072A5016676195 @default.
• W2029560072 hasAuthorship W2029560072A5019289252 @default.
• W2029560072 hasAuthorship W2029560072A5036514687 @default.
• W2029560072 hasAuthorship W2029560072A5050406332 @default.
• W2029560072 hasAuthorship W2029560072A5067659573 @default.
• W2029560072 hasAuthorship W2029560072A5082299340 @default.
• W2029560072 hasBestOaLocation W20295600722 @default.
• W2029560072 hasConcept C1008401 @default.
• W2029560072 hasConcept C105702510 @default.
• W2029560072 hasConcept C121608353 @default.
• W2029560072 hasConcept C126322002 @default.
• W2029560072 hasConcept C134018914 @default.
• W2029560072 hasConcept C185592680 @default.
• W2029560072 hasConcept C2776214593 @default.
• W2029560072 hasConcept C2776541429 @default.
• W2029560072 hasConcept C2776886416 @default.
• W2029560072 hasConcept C2777164284 @default.
• W2029560072 hasConcept C2777911890 @default.
• W2029560072 hasConcept C2779279991 @default.
• W2029560072 hasConcept C2779329777 @default.
• W2029560072 hasConcept C2780192828 @default.
• W2029560072 hasConcept C2781451080 @default.
• W2029560072 hasConcept C2910186798 @default.
• W2029560072 hasConcept C61367390 @default.
• W2029560072 hasConcept C71315377 @default.
• W2029560072 hasConcept C71924100 @default.
• W2029560072 hasConcept C8264082 @default.
• W2029560072 hasConceptScore W2029560072C1008401 @default.
• W2029560072 hasConceptScore W2029560072C105702510 @default.
• W2029560072 hasConceptScore W2029560072C121608353 @default.
• W2029560072 hasConceptScore W2029560072C126322002 @default.
• W2029560072 hasConceptScore W2029560072C134018914 @default.
• W2029560072 hasConceptScore W2029560072C185592680 @default.
• W2029560072 hasConceptScore W2029560072C2776214593 @default.

• next