FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029561230> ?p ?o ?g. }

• W2029561230 endingPage "3368" @default.
• W2029561230 startingPage "3357" @default.
• W2029561230 abstract "The crystal structures of the antigen-binding fragment of the murine monoclonal antibody (mAb) S25-39 in the presence of several antigens representing chlamydial lipopolysaccharide (LPS) epitopes based on the bacterial sugar 3-deoxy-α-d-manno-oct-2-ulosonic acid (Kdo) have been determined at resolutions from 2.4 to 1.8 Å. The antigen-binding site of this antibody differs from the well-characterized antibody S25-2 by a single mutation away from the germline of asparagine H53 to lysine, yet this one mutation results in a significant increase in avidity across a range of antigens. A comparison of the two antibody structures reveals that the mutated Lys H53 forms additional hydrogen bonds and/or charged-residue interactions with the second Kdo residue of every antigen having two or more carbohydrate residues. Significantly, the NH53K mutation results from a single nucleotide substitution in the germline sequence common among a panel of antibodies raised against glycoconjugates containing carbohydrate epitopes of chlamydial LPS. Like S25-2, S25-39 displays significant induced fit of complementarity determining region (CDR) H3 upon antigen binding, with the unliganded structure possessing a conformation distinct from those reported earlier for S25-2. The four different observed conformations for CDR H3 suggest that this CDR has evolved to exploit the recognition potential of a flexible loop while minimizing the associated entropic penalties of binding by adopting a limited number of ordered conformations in the unliganded state. These observations reveal strategies evolved to balance adaptability and specificity in the germline antibody response to carbohydrate antigens." @default.
• W2029561230 created "2016-06-24" @default.
• W2029561230 creator A5019622792 @default.
• W2029561230 creator A5028906387 @default.
• W2029561230 creator A5030855457 @default.
• W2029561230 creator A5040792982 @default.
• W2029561230 creator A5044809005 @default.
• W2029561230 creator A5050261718 @default.
• W2029561230 creator A5058650693 @default.
• W2029561230 creator A5074839838 @default.
• W2029561230 date "2011-04-01" @default.
• W2029561230 modified "2023-09-23" @default.
• W2029561230 title "A Common NH53K Mutation in the Combining Site of Antibodies Raised against Chlamydial LPS Glycoconjugates Significantly Increases Avidity" @default.
• W2029561230 cites W1501626447 @default.
• W2029561230 cites W1513105954 @default.
• W2029561230 cites W1590538302 @default.
• W2029561230 cites W1599651984 @default.
• W2029561230 cites W1837531904 @default.
• W2029561230 cites W1963681687 @default.
• W2029561230 cites W1964126053 @default.
• W2029561230 cites W1967197631 @default.
• W2029561230 cites W1982039072 @default.
• W2029561230 cites W1982679430 @default.
• W2029561230 cites W1983227647 @default.
• W2029561230 cites W1985605319 @default.
• W2029561230 cites W1988422289 @default.
• W2029561230 cites W1989652867 @default.
• W2029561230 cites W1995380127 @default.
• W2029561230 cites W2011796931 @default.
• W2029561230 cites W2021599177 @default.
• W2029561230 cites W2034450639 @default.
• W2029561230 cites W2038560210 @default.
• W2029561230 cites W2041108610 @default.
• W2029561230 cites W2048231797 @default.
• W2029561230 cites W2052538949 @default.
• W2029561230 cites W2055743905 @default.
• W2029561230 cites W2076747220 @default.
• W2029561230 cites W2081926288 @default.
• W2029561230 cites W2082660881 @default.
• W2029561230 cites W2083697648 @default.
• W2029561230 cites W2092278008 @default.
• W2029561230 cites W2102502668 @default.
• W2029561230 cites W2106531843 @default.
• W2029561230 cites W2109184569 @default.
• W2029561230 cites W2110447600 @default.
• W2029561230 cites W2111344966 @default.
• W2029561230 cites W2122104381 @default.
• W2029561230 cites W2134930545 @default.
• W2029561230 cites W2137015675 @default.
• W2029561230 cites W2143467722 @default.
• W2029561230 cites W2143701639 @default.
• W2029561230 cites W2144081223 @default.
• W2029561230 cites W2144718643 @default.
• W2029561230 cites W2146948320 @default.
• W2029561230 cites W2148495628 @default.
• W2029561230 cites W2158686006 @default.
• W2029561230 cites W2160899789 @default.
• W2029561230 cites W2163341755 @default.
• W2029561230 cites W2173272774 @default.
• W2029561230 cites W4231755100 @default.
• W2029561230 cites W4240784007 @default.
• W2029561230 cites W4245248161 @default.
• W2029561230 cites W96261946 @default.
• W2029561230 doi "https://doi.org/10.1021/bi101886v" @default.
• W2029561230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21405106" @default.
• W2029561230 hasPublicationYear "2011" @default.
• W2029561230 type Work @default.
• W2029561230 sameAs 2029561230 @default.
• W2029561230 citedByCount "15" @default.
• W2029561230 countsByYear W20295612302012 @default.
• W2029561230 countsByYear W20295612302013 @default.
• W2029561230 countsByYear W20295612302014 @default.
• W2029561230 countsByYear W20295612302015 @default.
• W2029561230 countsByYear W20295612302016 @default.
• W2029561230 countsByYear W20295612302018 @default.
• W2029561230 countsByYear W20295612302019 @default.
• W2029561230 countsByYear W20295612302022 @default.
• W2029561230 crossrefType "journal-article" @default.
• W2029561230 hasAuthorship W2029561230A5019622792 @default.
• W2029561230 hasAuthorship W2029561230A5028906387 @default.
• W2029561230 hasAuthorship W2029561230A5030855457 @default.
• W2029561230 hasAuthorship W2029561230A5040792982 @default.
• W2029561230 hasAuthorship W2029561230A5044809005 @default.
• W2029561230 hasAuthorship W2029561230A5050261718 @default.
• W2029561230 hasAuthorship W2029561230A5058650693 @default.
• W2029561230 hasAuthorship W2029561230A5074839838 @default.
• W2029561230 hasConcept C104317684 @default.
• W2029561230 hasConcept C109825262 @default.
• W2029561230 hasConcept C13426554 @default.
• W2029561230 hasConcept C147483822 @default.
• W2029561230 hasConcept C153911025 @default.
• W2029561230 hasConcept C159654299 @default.
• W2029561230 hasConcept C179223381 @default.
• W2029561230 hasConcept C185592680 @default.
• W2029561230 hasConcept C195616568 @default.
• W2029561230 hasConcept C2775895851 @default.
• W2029561230 hasConcept C501734568 @default.
• W2029561230 hasConcept C515207424 @default.

• next