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- W2029562489 abstract "Numerous chemicals increase the metabolic capability of organisms by their ability to activate genes encoding various xenochemical-metabolizing enzymes, such as cytochromes P450 (CYPs), transferases and transporters. For example, natural and synthetic glucocorticoids (agonists and antagonists) as well as other clinically important drugs induce the hepatic CYP2B, CYP2C and CYP3A subfamilies in man, and these inductions might lead to clinically important drug-drug interactions. Only recently, the key cellular receptors that mediate such inductions have been identified. They include nuclear receptors, such as the constitutive androstane receptor (CAR, NR1I3), the retinoid X receptor (RXR, NR2B1), the pregnane X receptor (PXR, NR1I2), and the vitamin D receptor (VDR, NR1I1) and steroid receptors such as the glucocorticoid receptor (GR, NR3C1). There is a wide promiscuity of these receptors in the induction of CYPs in response to xenobiotics. Indeed, this adaptive system appears now as a tangle of networks, where receptors share partners, ligands, DNA response elements and target genes. Moreover, they influence mutually their relative expression. This review is focused on these different pathways controlling human CYP2B6, CYP2C9 and CYP3A4 gene expression, and the cross-talk between these pathways." @default.
- W2029562489 created "2016-06-24" @default.
- W2029562489 creator A5007151822 @default.
- W2029562489 creator A5025780107 @default.
- W2029562489 creator A5028772377 @default.
- W2029562489 creator A5046103946 @default.
- W2029562489 creator A5082729820 @default.
- W2029562489 date "2003-02-01" @default.
- W2029562489 modified "2023-10-16" @default.
- W2029562489 title "The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors" @default.
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- W2029562489 doi "https://doi.org/10.1016/s0304-4165(02)00483-x" @default.
- W2029562489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12573484" @default.
- W2029562489 hasPublicationYear "2003" @default.
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