FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029563691> ?p ?o ?g. }

• W2029563691 endingPage "3159" @default.
• W2029563691 startingPage "3149" @default.
• W2029563691 abstract "Structural changes in Purkinje cells have been identified in the essential tremor cerebellum, although the mechanisms that underlie these changes remain poorly understood. Climbing fibres provide one of the major excitatory inputs to Purkinje cells, and climbing fibre-Purkinje cell connections are essential for normal cerebellar-mediated motor control. The distribution of climbing fibre-Purkinje cell synapses on Purkinje cell dendrites is dynamically regulated and may be altered in disease states. The aim of the present study was to examine the density and distribution of climbing fibre-Purkinje cell synapses using post-mortem cerebellar tissue of essential tremor cases and controls. Using vesicular glutamate transporter type 2 immunohistochemistry, we labelled climbing fibre-Purkinje cell synapses of 12 essential tremor cases and 13 age-matched controls from the New York Brain Bank. Normally, climbing fibres form synapses mainly on the thick, proximal Purkinje cell dendrites in the inner portion of the molecular layer, whereas parallel fibres form synapses on the thin, distal Purkinje cell spiny branchlets. We observed that, compared with controls, essential tremor cases had decreased climbing fibre-Purkinje cell synaptic density, more climbing fibres extending to the outer portion of the molecular layer, and more climbing fibre-Purkinje cell synapses on the thin Purkinje cell spiny branchlets. Interestingly, in essential tremor, the increased distribution of climbing fibre-Purkinje cell synapses on the thin Purkinje cell branchlets was inversely associated with clinical tremor severity, indicating a close relationship between the altered distribution of climbing fibre-Purkinje cell connections and tremor. These findings suggest that abnormal climbing fibre-Purkinje cell connections could be of importance in the pathogenesis of essential tremor." @default.
• W2029563691 created "2016-06-24" @default.
• W2029563691 creator A5009039130 @default.
• W2029563691 creator A5009912552 @default.
• W2029563691 creator A5026333864 @default.
• W2029563691 creator A5062004674 @default.
• W2029563691 creator A5063266090 @default.
• W2029563691 creator A5081733290 @default.
• W2029563691 date "2014-10-01" @default.
• W2029563691 modified "2023-10-15" @default.
• W2029563691 title "Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum" @default.
• W2029563691 cites W1490581643 @default.
• W2029563691 cites W1502350310 @default.
• W2029563691 cites W1519429687 @default.
• W2029563691 cites W1857922832 @default.
• W2029563691 cites W1965888651 @default.
• W2029563691 cites W1970417678 @default.
• W2029563691 cites W1984824987 @default.
• W2029563691 cites W1987392663 @default.
• W2029563691 cites W1987778458 @default.
• W2029563691 cites W1995607576 @default.
• W2029563691 cites W2008470349 @default.
• W2029563691 cites W2014107651 @default.
• W2029563691 cites W2015001118 @default.
• W2029563691 cites W2028474222 @default.
• W2029563691 cites W2029602157 @default.
• W2029563691 cites W2031133527 @default.
• W2029563691 cites W2032330693 @default.
• W2029563691 cites W2033347666 @default.
• W2029563691 cites W2037502405 @default.
• W2029563691 cites W2040206045 @default.
• W2029563691 cites W2040208273 @default.
• W2029563691 cites W2043895241 @default.
• W2029563691 cites W2044270926 @default.
• W2029563691 cites W2050235958 @default.
• W2029563691 cites W2058001458 @default.
• W2029563691 cites W2060267134 @default.
• W2029563691 cites W2068513296 @default.
• W2029563691 cites W2069952262 @default.
• W2029563691 cites W2074146584 @default.
• W2029563691 cites W2083093103 @default.
• W2029563691 cites W2087292300 @default.
• W2029563691 cites W2087650729 @default.
• W2029563691 cites W2090341908 @default.
• W2029563691 cites W2091739570 @default.
• W2029563691 cites W2093650784 @default.
• W2029563691 cites W2103342211 @default.
• W2029563691 cites W2103903707 @default.
• W2029563691 cites W2104321133 @default.
• W2029563691 cites W2106656283 @default.
• W2029563691 cites W2107902339 @default.
• W2029563691 cites W2114911122 @default.
• W2029563691 cites W2119835245 @default.
• W2029563691 cites W2122922916 @default.
• W2029563691 cites W2126013729 @default.
• W2029563691 cites W2137794576 @default.
• W2029563691 cites W2150014159 @default.
• W2029563691 cites W2161785525 @default.
• W2029563691 cites W2413638063 @default.
• W2029563691 cites W2473923968 @default.
• W2029563691 cites W4235938152 @default.
• W2029563691 cites W4240271581 @default.
• W2029563691 cites W4245552230 @default.
• W2029563691 cites W4320995227 @default.
• W2029563691 doi "https://doi.org/10.1093/brain/awu281" @default.
• W2029563691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4240294" @default.
• W2029563691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25273997" @default.
• W2029563691 hasPublicationYear "2014" @default.
• W2029563691 type Work @default.
• W2029563691 sameAs 2029563691 @default.
• W2029563691 citedByCount "106" @default.
• W2029563691 countsByYear W20295636912015 @default.
• W2029563691 countsByYear W20295636912016 @default.
• W2029563691 countsByYear W20295636912017 @default.
• W2029563691 countsByYear W20295636912018 @default.
• W2029563691 countsByYear W20295636912019 @default.
• W2029563691 countsByYear W20295636912020 @default.
• W2029563691 countsByYear W20295636912021 @default.
• W2029563691 countsByYear W20295636912022 @default.
• W2029563691 countsByYear W20295636912023 @default.
• W2029563691 crossrefType "journal-article" @default.
• W2029563691 hasAuthorship W2029563691A5009039130 @default.
• W2029563691 hasAuthorship W2029563691A5009912552 @default.
• W2029563691 hasAuthorship W2029563691A5026333864 @default.
• W2029563691 hasAuthorship W2029563691A5062004674 @default.
• W2029563691 hasAuthorship W2029563691A5063266090 @default.
• W2029563691 hasAuthorship W2029563691A5081733290 @default.
• W2029563691 hasBestOaLocation W20295636911 @default.
• W2029563691 hasConcept C105702510 @default.
• W2029563691 hasConcept C169760540 @default.
• W2029563691 hasConcept C18903297 @default.
• W2029563691 hasConcept C2778058767 @default.
• W2029563691 hasConcept C2778472085 @default.
• W2029563691 hasConcept C2779652256 @default.
• W2029563691 hasConcept C2780393176 @default.
• W2029563691 hasConcept C86803240 @default.
• W2029563691 hasConcept C95038775 @default.
• W2029563691 hasConceptScore W2029563691C105702510 @default.

• next