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• W2029565780 endingPage "e17417" @default.
• W2029565780 startingPage "e17417" @default.
• W2029565780 abstract "The flow of information between neurons in many neural circuits is controlled by a highly specialized site of cell-cell contact known as a synapse. A number of molecules have been identified that are involved in central nervous system synapse development, but knowledge is limited regarding whether these cues direct organization of specific synapse types or on particular regions of individual neurons. Glutamate is the primary excitatory neurotransmitter in the brain, and the majority of glutamatergic synapses occur on mushroom-shaped protrusions called dendritic spines. Changes in the morphology of these structures are associated with long-lasting modulation of synaptic strength thought to underlie learning and memory, and can be abnormal in neuropsychiatric disease. Here, we use rat cortical slice cultures to examine how a previously-described synaptogenic molecule, the EphB2 receptor tyrosine kinase, regulates dendritic protrusion morphology in specific regions of the dendritic arbor in cortical pyramidal neurons. We find that alterations in EphB2 signaling can bidirectionally control protrusion length, and knockdown of EphB2 expression levels reduces the number of dendritic spines and filopodia. Expression of wild-type or dominant negative EphB2 reveals that EphB2 preferentially regulates dendritic protrusion structure in basal dendrites. Our findings suggest that EphB2 may act to specify synapse formation in a particular subcellular region of cortical pyramidal neurons." @default.
• W2029565780 created "2016-06-24" @default.
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• W2029565780 date "2011-02-25" @default.
• W2029565780 modified "2023-09-23" @default.
• W2029565780 title "Preferential Control of Basal Dendritic Protrusions by EphB2" @default.
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• W2029565780 doi "https://doi.org/10.1371/journal.pone.0017417" @default.
• W2029565780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3045449" @default.
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